1. Apoptosis
  2. Apoptosis
  3. GPNA hydrochloride

GPNA hydrochloride 

Cat. No.: HY-W011391 Purity: 99.91%
Handling Instructions

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells.

For research use only. We do not sell to patients.

GPNA hydrochloride Chemical Structure

GPNA hydrochloride Chemical Structure

CAS No. : 67953-08-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Estimated Time of Arrival: December 31
100 mg USD 225 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].

IC50 & Target

ASCT2[1]

In Vitro

GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1].

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 10, 100, 250, 500 , and 1000 μM
Incubation Time: 48 hours
Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM.
Molecular Weight

303.70

Formula

C₁₁H₁₄ClN₃O₅

CAS No.

67953-08-6

SMILES

OC([[email protected]@H](N)CCC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (411.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2927 mL 16.4636 mL 32.9272 mL
5 mM 0.6585 mL 3.2927 mL 6.5854 mL
10 mM 0.3293 mL 1.6464 mL 3.2927 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

GPNAApoptosisγ-glutamyltransferaseGGTglutamineGlntransporterASCT2SNATLATapoptosisA549lungInhibitorinhibitorinhibit

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Product name:
GPNA hydrochloride
Cat. No.:
HY-W011391
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