2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage
  3. EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker
  4. QBS10072S

QBS10072S is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 μM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 μM). QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S can be used for the research of glioblastoma and aggressive T-cell lymphoma.

For research use only. We do not sell to patients.

QBS10072S

QBS10072S Chemical Structure

CAS No. : 1802735-28-9

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QBS10072S Related Antibodies

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Description

QBS10072S is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 μM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 μM). QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S can be used for the research of glioblastoma and aggressive T-cell lymphoma[1][2].

Clinical Trial
Molecular Weight

333.25

Formula

C15H22Cl2N2O2
CAS No.
SMILES

CC1=C(C[C@@H](CC(O)=O)N)C=C(N(CCCl)CCCl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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QBS10072S Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QBS10072S1802735-28-9EAATDNA/RNA SynthesisDNA Alkylator/CrosslinkerExcitatory amino acid transporter Glutamate transporter| MDA-MB-231TNBCleptomeningeal spreadBBB penetrableInhibitorinhibitorinhibit

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