L-Ala-BPA
Based on 1 Customer Validation
L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2941355-27-5
- Formula: C12H17BN2O5
- Molecular Weight:280.08
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in AsPC-1 cells via the PEPT1/2 transport pathway[1].
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in FaDu cells via the LAT-1 transport pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colon carcinoma BALB/c mice[1]
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Dosage:200 mg/kg
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Administration:i.v.; single bolus dose; 90 minutes prior to neutron irradiation
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Result:Induced complete and durable tumor control through the study endpoint.
Produced a 34% growth delay in non-irradiated abscopal tumors.
Chemical Information
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CAS No. 2941355-27-5
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Appearance Solid
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Molecular Weight 280.08
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Formula C12H17BN2O5
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Color White to off-white
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SMILES
OB(O)C1=CC=C(C[C@H](NC([C@H](C)N)=O)C(O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)