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Cat. No.: HY-183513

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L-Ala-BPA

L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT).

For research use only. We do not sell to patients.

CAS No.: 2941355-27-5
Formula: C₁₂H₁₇BN₂O₅
Molecular Weight:280.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-Ala-BPA Chemical Structure

CAS No.: 2941355-27-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

L-Ala-BPA (2 h) mediates dose-dependent boron uptake in AsPC-1 cells via the PEPT1/2 transport pathway^[1].
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in FaDu cells via the LAT-1 transport pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-Ala-BPA (200 mg/kg; i.v.; single bolus dose; 90 minutes prior to neutron irradiation) plus 12-minute neutron irradiation produces complete, durable tumor control in syngeneic CT26 colon carcinoma-bearing BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Colon carcinoma BALB/c mice^[1]
Dosage:

200 mg/kg
Administration:

i.v.; single bolus dose; 90 minutes prior to neutron irradiation
Result:

Induced complete and durable tumor control through the study endpoint.
Produced a 34% growth delay in non-irradiated abscopal tumors.

Chemical Information

CAS No. 2941355-27-5
Molecular Weight 280.08
Formula C₁₂H₁₇BN₂O₅
SMILES

OB(O)C1=CC=C(C[C@H](NC([C@H](C)N)=O)C(O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Samkeliso Dlamini, et al. Highly Soluble Prodrug 4-1-Boronophenylalanine (L-BPA) Containing Dipeptide Exhibits Notable Tumor Suppression whi Vaccine Effect And Abscopal Tumor Suppression Post Neutron Irradiation Treatment. April 202686(7_Supplement):4641-4641.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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