ABL2 Antibody (YA4736)
(Synonyms: ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG)ABL2 Antibody (YA4736) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ABL2.
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Host:
Mouse
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Application:
ICC/IF, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
ABL2 Antibody (YA4736) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ABL2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 128 kDa;
Purified recombinant fragment of Arg expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ABL2 is a non-receptor tyrosine protein kinase that plays overlapping roles with ABL1 in key processes of cell growth and survival, such as cytoskeleton remodeling in response to extracellular stimuli, cell movement and adhesion, and receptor endocytosis. ABL2 coordinates actin remodeling by tyrosine phosphorylation of proteins that control cytoskeleton dynamics, such as MYH10 (involved in movement), CTTN (involved in signal transduction), or TUBA1 and TUBB (microtubule subunits). It directly binds to F-actin and regulates actin cytoskeleton structure through its F-actin bundle activity. ABL2 participates in the regulation of cell adhesion and movement by phosphorylating key regulators such as CRK, CRKL, DOK1, or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its binding to RASA1, thereby recruiting ARHGAP35 to the cell periphery, where it inhibits RHO. ABL2 phosphorylates multiple receptor tyrosine kinases, such as PDGFRB, and other substrates involved in the regulation of endocytosis, such as RIN1.
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Subcellular Localization
Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:Broad expression -
Isoforms & Post-Translational Modification
P42684 has 9 isomers: P42684-1: 128343 Da (predicted); P42684-2: 124560 Da (predicted); P42684-3: 126684 Da (predicted); P42684-4: 114159 Da (predicted); P42684-5: 117942 Da (predicted); P42684-6: 126219 Da (predicted); P42684-7: 115817 Da (predicted); P42684-10: 116283 Da (predicted); P42684-8: 60864 Da (predicted).
Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity);Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation -
Subunit
Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases
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SwissProt ID
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Synonyms
ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
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