BCR-ABL-IN-14
BCR-ABL-IN-14 is a tyrosine kinase inhibitor targeting BCR-ABL1, ABL1 and ABL2. BCR-ABL-IN-14 inhibits chronic myeloid leukemia cells. It is applicable to research related to chronic myeloid leukemia, acute myeloid leukemia and acute lymphoblastic leukemia.
For research use only. We do not sell to patients.
- CAS No.: 2412969-11-8
- Formula: C22H18ClF4N5O3
- Molecular Weight:511.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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BCR-ABL1 |
ABL1 |
Abl2 |
Example 230 (example 230) (0.3-2000 nM; 72 h) exhibits antiproliferative activity in K562 chronic myeloid leukemia cells, with a CC50 of 6.98 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2412969-11-8
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Molecular Weight 511.86
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Formula C22H18ClF4N5O3
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SMILES
OC[C@H](N1C2=C(C3=NNC=C3)C=C(C=C2N=C1C(F)F)C(NC4=CC=C(C=C4)OC(F)(F)Cl)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)