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Cat. No.: HY-185916

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BCR-ABL-IN-14

BCR-ABL-IN-14 is a tyrosine kinase inhibitor targeting BCR-ABL1, ABL1 and ABL2. BCR-ABL-IN-14 inhibits chronic myeloid leukemia cells. It is applicable to research related to chronic myeloid leukemia, acute myeloid leukemia and acute lymphoblastic leukemia.

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CAS No.: 2412969-11-8
Formule: C₂₂H₁₈ClF₄N₅O₃
Masse moléculaire:511.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

BCR-ABL-IN-14 Chemical Structure

CAS No.: 2412969-11-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Description
- IC₅₀ & Target
- In Vitro
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Description

IC₅₀ & Target

^[1]

BCR-ABL1

ABL1

Abl2

Voir tous les produits spécifiques à Isoform Bcr-Abl :

Abl
Bcr-Abl

In Vitro

Anti-cancer

BCR-ABL-IN-14 (example 230) (0.3-2000 nM; 72 h) exhibits antiproliferative activity in K562 chronic myeloid leukemia cells, with a CC₅₀ of 6.98 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2412969-11-8
Masse moléculaire 511.86
Formule C₂₂H₁₈ClF₄N₅O₃
SMILES

OC[C@H](N1C2=C(C3=NNC=C3)C=C(C=C2N=C1C(F)F)C(NC4=CC=C(C=C4)OC(F)(F)Cl)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Romero FA, et al. Compounds for treating certain leukemias. United States Patent Application No. US 2020/0087283 A1. Published March 19, 2020.

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Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BCR-ABL-IN-14

Voir tous les produits spécifiques à Isoform Bcr-Abl

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Description

IC50 & Target

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Chemical Information

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