PAG1 - phosphoprotein membrane anchor with glycosphingolipid microdomains 1 Gene

Also Known as CBP; PAG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55824

About PAG1

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:80,967,810-81,112,068 (from NCBI)

This gene has 4 transcripts (splice variants) and 193 orthologues. Broad expression in lymph node (RPKM 8.7), placenta (RPKM 8.2) and 25 other tissues.

Summary

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]

PAG1 Products (1)

mRNA Protein Name
NM_018440.4 NP_060910.3 phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
10790433 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10790433 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10790433 GOA
involved in regulation of T cell activation IDA
IDA: Inferred from direct assay
10790433 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane raft IDA
IDA: Inferred from direct assay
10790433 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10790433 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAG1 Protein Structure

PAG

PAG: Phosphoprotein associated with glycosphingolipid-enriched (1 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

phosphoprotein associated with glycosphingolipid-enriched microdomains 1

  • Csk-binding protein

PAG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAG1 Q9NWQ8 CSK Homo sapiens P41240
Anti Bait CoIP
18070987
Intra
PAG1 Q9NWQ8 RACK1 Homo sapiens P63244
Anti Bait CoIP
23866081
Intra
PAG1 Q9NWQ8 FYN Homo sapiens P06241
Peptide Array
18056706
Intra
PAG1 Q9NWQ8 FYN Homo sapiens P06241
CoIP
18056706
Intra
PAG1 Q9NWQ8 LYN Homo sapiens P07948
Anti Bait CoIP
18070987
Intra
PAG1 Q9NWQ8 LYN Homo sapiens P07948
Anti Bait CoIP
23866081
Cross: Cross-species interaction Intra: Intraspecies interaction

PAG1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82223 PAG1 Antibody (YA1968) WB, IHC-P, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Chromosome 8q21.11 Deletion Syndrome

  • 8q21.11 Microdeletion Syndrome

  • Del(8)(Q21.11)

  • Deletion 8q21.11

  • Monosomy 8q21.11
B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy

  • B-All With Hypodiploidy

  • Hypodiploid All
Peters-Plus Syndrome

  • Krause-Kivlin Syndrome

  • Peters Plus Syndrome

  • Peters Anomaly

  • Irido-Corneo-Trabecular Dysgenesis

  • PTRPLS

  • Peters Anomaly With Short-Limb Dwarfism

  • Peters Anomaly-Short Limb Dwarfism Syndrome

  • Peters Anomaly With Short Limb Dwarfism

  • Peters Congenital Glaucoma

  • Krause-Van Schooneveld-Kivlin Syndrome

  • Peters' Plus Syndrome

  • Peters'-Plus Syndrome

  • Anomaly Peters
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09971 PAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17709 Pappa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18364 Pag1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24843 Pag1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PAG1 VGNC VGNC:32553
Felis catus PAG1 VGNC VGNC:64025
Rattus norvegicus PAG1 RGD RGD:620394
Canis familiaris PAG1 VGNC VGNC:44242
Mus musculus PAG1 MGD MGI:2443160
Macaca mulatta PAG1 VGNC VGNC:75698
Others PAG1 NCBI