ARHGAP33 - Rho GTPase activating protein 33 Gene

Also Known as SNX26; TCGAP; NOMA-GAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115703

About ARHGAP33

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,775,564-35,788,822 (from NCBI)

This gene has 12 transcripts (splice variants), 112 orthologues and 3 paralogues. Broad expression in testis (RPKM 7.3), brain (RPKM 5.7) and 23 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

ARHGAP33 Products (3)

mRNA Protein Name
NM_001172630.2 NP_001166101.1 rho GTPase-activating protein 33 isoform 2
NM_001366178.1 NP_001353107.1 rho GTPase-activating protein 33 isoform 3
NM_052948.4 NP_443180.2 rho GTPase-activating protein 33 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16777849 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20873783 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP33 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (193 - 244)

RhoGAP

RhoGAP: RhoGAP domain (329 - 475)

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  • 1126 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 33

  • neurite outgrowth multiadaptor RhoGAP protein

ARHGAP33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGAP33 O14559 FYN Homo sapiens P06241
Anti Bait CoIP
16777849
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noma

  • Cancrum Oris

  • Gangrenous Stomatitis

  • Oro-Facial Gangrene

  • Noma Neonatorum

  • Oral Gangrene

  • Oro-Facial Noma

  • Stomatitis Gangrenosa

  • Stomatonecrosis

  • Gangrene Stomatitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00932 ARHGAP33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP33 RGD RGD:2318374
Bos taurus ARHGAP33 VGNC VGNC:26091
Macaca mulatta ARHGAP33 VGNC VGNC:69887
Mus musculus ARHGAP33 MGD MGI:2673998
Canis familiaris ARHGAP33 VGNC VGNC:84858
Felis catus ARHGAP33 VGNC VGNC:59890
Others ARHGAP33 NCBI