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FYB1 - FYN binding protein 1 Gene

Also Known as FYB; ADAP; THC3; PRO0823; SLAP130; SLAP-130

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2533

About FYB1

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:39,105,252-39,274,528 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in appendix (RPKM 36.5), lymph node (RPKM 32.7) and 15 other tissues.

Summary

The protein encoded by this gene is an adapter for the Fyn protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FYB1 Products (5)

mRNA	Protein	Name
NM_001243093.2	NP_001230022.1	FYN-binding protein 1 isoform 3
NM_001349333.2	NP_001336262.1	FYN-binding protein 1 isoform 1
NM_001465.6	NP_001456.3	FYN-binding protein 1 isoform 1
NM_018594.2	NP_061064.2	FYN-binding protein 1 isoform 4
NM_199335.5	NP_955367.1	FYN-binding protein 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10409671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FYB1 Protein Structure

SH3_2

hSH3

0
200
400
600
783 a.a.

Protein Preferred Names	Protein Names
FYN-binding protein 1	FYB-120/130

FYB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	Anti Bait CoIP	16461356
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	Far-WB	16461356
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	SPR	16461356
Intra	FYB1	O15117	SKAP1	Homo sapiens	Q86WV1	TAP	19798671
Intra	FYB1	O15117	LCP2	Homo sapiens	Q13094	CoIP	9207119
Intra	FYB1	O15117	LCP2	Homo sapiens	Q13094	Pull Down	22074159
Intra	FYB1	O15117	LCP2	Homo sapiens	Q13094	CoIP	10570256
Intra	FYB1	O15117	NCK1	Homo sapiens	P16333	Pull Down	22074159
Intra	FYB1	O15117	NCK2	Homo sapiens	O43639	Pull Down	22074159

Cross: Cross-species interaction Intra: Intraspecies interaction

FYB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81276	FYB Antibody (YA973)	WB	Human
HY-P81276B	FYB Antibody (YA974)	WB, IHC-P, ICC/IF	Mouse, Human
HY-P85430	FYB Antibody (YA5122)	WB	Human, Rat

Related Diseases

Diseases	Alias
Thrombocytopenia 3	THC3 Thrombocytopenia, Autosomal Recessive, 3
Congenital Autosomal Recessive Small-Platelet Thrombocytopenia	Carst
Plasmodium Vivax Malaria	Malaria, Vivax Malaria By Plasmodium Vivax Vivax Malaria Malaria Vivax
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Blood Group Incompatibility
Rh Isoimmunization	Rh Incompatibility Affecting Management Of Mother
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Hemoglobinopathy	Hemoglobinopathies
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05172	FYB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FYB1	VGNC	VGNC:72831
Canis familiaris	FYB1	VGNC	VGNC:41024
Bos taurus	FYB1	VGNC	VGNC:29160
Mus musculus	FYB1	MGD	MGI:1346327
Felis catus	FYB1	VGNC	VGNC:62398
Rattus norvegicus	FYB1	RGD	RGD:1563421
Others	FYB1	NCBI