2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. FYB Antibody (YA973)

FYB Antibody (YA973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FYB.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

FYB Antibody (YA973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FYB.
Host

Mouse
Clonality

Monoclonal
Molecular Weight
Predicted band size: 85 kDa;
Observed band size: 120 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant human FYB protein fragments expressed in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG1  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity)
Subcellular Localization：Cytoplasm; Nucleus; Cell junction
Expression：
Tissue_specificity:It is expressed in hematopoietic tissues (such as myeloid cells and T cells) , spleen, and thymus. It is not expressed in B cells and non-lymphoid tissues.
Isoforms & Post-Translational Modification：O15117 has 3 isomers: O15117-1: 85387 Da (predicted); O15117-2: 90606 Da (predicted); O15117-3: 91651 Da (predicted).
T-cell receptor ligation leads to increased tyrosine phosphorylation
Subunit：Part of a complex consisting of SKAP2, FYB1, LILRB3 and PTPNS1 (By similarity).
Database

Entrez Gene: 2533 Human

SwissProt: O15117 Human

OMIM: 273900 Human

Research Field

Signal Transduction
Synonyms
ADAP; Fyb; FYN binding protein; p120/p130; SLAP130
Documentation
User Guide for Antibodies (1077 KB)
References

FYB Antibody (YA973) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FYB Antibody (YA973)
Cat. No.:
HY-P81276
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