FYB Antibody (YA5122)
(Synonyms: FYB; SLAP130; FYN-binding protein; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein)FYB Antibody (YA5122) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FYB.
-
Host:
Mouse
-
Application:
WB
-
Reactivity :
Human, Rat
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:1000-1:2000 |
Product Details
FYB Antibody (YA5122) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FYB.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Rat
-
Calculated Molecular Weight Predicted band size: 85 kDa;
Purified recombinant human Fyb protein fragments expressed in E.coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
FYB acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells[1][2][3].
-
Subcellular Localization
Cytoplasm; Nucleus; Cell junction
-
Expression
Tissue_specificity:It is expressed in hematopoietic tissues (such as myeloid cells and T cells) , spleen, and thymus. It is not expressed in B cells and non-lymphoid tissues. -
Isoforms & Post-Translational Modification
O15117 has 3 isomers: O15117-1: 85387 Da (predicted); O15117-2: 90606 Da (predicted); O15117-3: 91651 Da (predicted).
T-cell receptor ligation leads to increased tyrosine phosphorylation -
Subunit
Part of a complex consisting of SKAP2, FYB1, LILRB3 and PTPNS1 (By similarity).
-
SwissProt ID
-
Synonyms
FYB; SLAP130; FYN-binding protein; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein
Documentation
Powered by Bioz
