HTR6 - 5-hydroxytryptamine receptor 6 Gene

Also Known as 5-HT6; 5-HT6R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3362

About HTR6

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,664,875-19,680,966 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates Adenylate Cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

HTR6 Products (1)

mRNA Protein Name
NM_000871.3 NP_000862.1 5-hydroxytryptamine receptor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
35714614 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17189269 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
35714614 GOA
involved in positive regulation of TOR signaling IDA
IDA: Inferred from direct assay
23027611 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
37327704 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR6 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 320)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 6

  • 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

  • serotonin receptor 6

HTR6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HTR6 P50406 FYN Homo sapiens P06241
Y2H
17189269
Intra
HTR6 P50406 FYN Homo sapiens P06241
Anti Tag CoIP
17189269
Intra
HTR6 P50406 FYN Homo sapiens P06241
Anti Bait CoIP
17189269
Intra
HTR6 P50406 FYN Homo sapiens P06241
Pull Down
17189269
Intra
HTR6 P50406 MAP1B Homo sapiens P46821
Pull Down
24614691
Intra
HTR6 P50406 MAP1B Homo sapiens P46821
Y2H
24614691
Intra
HTR6 P50406 MAP1B Homo sapiens P46821
Anti Tag CoIP
24614691
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mood Disorder

  • Mood Disorders

  • Episodic Mood Disorder
Meckel Syndrome, Type 1

  • Meckel Syndrome

  • Meckel-Gruber Syndrome

  • Dysencephalia Splanchnocystica

  • Meckel Syndrome 1

  • MKS1

  • Mks

  • Gruber Syndrome

  • Meckel-Gruber Syndrome, Type 1

  • Mes

  • Dysencephalia Splachnocystica

  • Meckel Gruber Syndrome

  • Meckel Syndrome Type 1
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06480 HTR6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06481 Htr6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06482 Htr6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HTR6 VGNC VGNC:80238
Macaca mulatta HTR6 VGNC VGNC:106385
Canis familiaris HTR6 VGNC VGNC:41833
Bos taurus HTR6 VGNC VGNC:30002
Mus musculus HTR6 MGD MGI:1196627
Rattus norvegicus HTR6 RGD RGD:62044
Others HTR6 NCBI