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  2. HTR6 - 5-hydroxytryptamine receptor 6 Gene

HTR6 - 5-hydroxytryptamine receptor 6 Gene

Homo sapiens

Also known as 5-HT6; 5-HT6R

Gene ID: 3362 | Gene type: protein coding

About HTR6

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,664,875-19,680,966 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates Adenylate Cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

HTR6 Products(1)

mRNA Protein Name
NM_000871.3 NP_000862.1 5-hydroxytryptamine receptor 6

HTR6 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 320)

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  • 440 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 6

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

serotonin receptor 6

Related Diseases

Diseases Alias
Mood Disorder

Mood Disorders

Episodic Mood Disorder

Meckel Syndrome, Type 1

Meckel Syndrome

Meckel-Gruber Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus HTR6 VGNC VGNC:80238
Macaca mulatta HTR6 VGNC VGNC:106385
Canis familiaris HTR6 VGNC VGNC:41833
Bos taurus HTR6 VGNC VGNC:30002
Mus musculus HTR6 MGD MGI:1196627
Rattus norvegicus HTR6 RGD RGD:62044