2. PI3K/Akt/mTOR Stem Cell/Wnt Protein Tyrosine Kinase/RTK Neuronal Signaling Cytoskeleton Cell Cycle/DNA Damage
  3. GSK-3 Src DYRK Tau Protein Microtubule/Tubulin
  4. ARN25699

ARN25699 is a kinase inhibitor with an IC50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability. ARN25699 reduces hyperphosphorylation of tau protein and promotes microtubule bundle formation. ARN25699 has a broader kinome inhibitory profile and targets kinases associated with the pathogenic mechanisms linked to Alzheimer's disease. ARN25699 can be used in the research of Alzheimer's disease and related tauopathies.

For research use only. We do not sell to patients.

ARN25699

ARN25699 Chemical Structure

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ARN25699 Related Antibodies

Top Publications Citing Use of Products

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GSK-3 GSK-3α GSK-3β

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Description

ARN25699 is a kinase inhibitor with an IC50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability. ARN25699 reduces hyperphosphorylation of tau protein and promotes microtubule bundle formation. ARN25699 has a broader kinome inhibitory profile and targets kinases associated with the pathogenic mechanisms linked to Alzheimer's disease. ARN25699 can be used in the research of Alzheimer's disease and related tauopathies[1].

IC50 & Target[1]

GSK-3β

 

DYRK1A

 

Fyn-α

 

In Vitro

ARN25699 (Compound 28) (0.1-10 μM) inhibits a subset of kinases associated with the pathogenesis of Alzheimer's disease[1].
ARN25699 (1-100 μM; 6 h) induces dose-dependent microtubule bundle formation in Tau0N4R-TM-tGFP U2OS cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ARN25699 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax AUC T1/2 Vd CL
Mice[1] 3 mg/kg i.v. 4737 ng/mL 5 min 54854 min·ng/mL 141 min 10.0 L/kg 50 mL/min/kg
Mice[1] 10 mg/kg p.o. 13 ng/mL 30 min 623 min·ng/mL / / /
Molecular Weight

403.44

Formula

C21H21N7O2
SMILES

O=C(N)C1=CC=CC(CNC2=NC(NC3=NNC(C4CCC4)=C3)=C(OC=C5)C5=N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ARN25699 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARN25699ARN 25699ARN-25699GSK-3SrcDYRKTau ProteinMicrotubule/TubulinGlycogen synthase kinase-3Glycogen synthase kinase 3Dual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseFYN-αGSK-3βHLMsCD1 micetauopathiesDYRK1AAlzheimer’s diseasemicrotubule bundle formationU2OS cellstau hyperphosphorylationInhibitorinhibitorinhibit

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