2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt PI3K/Akt/mTOR Immunology/Inflammation
  3. Src GSK-3 NO Synthase
  4. Fyn-IN-1

Fyn-IN-1 (Compound 43) is a selective, blood-brain barrier permeable Fyn and GSK-3β inhibitor with IC50 values of 0.044 μM and 0.61 μM, respectively. Fyn-IN-1 significantly downregulates the pro-inflammatory enzyme iNOS. Fyn-IN-1 can be used in the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

Fyn-IN-1

Fyn-IN-1 Chemical Structure

CAS No. : 3107638-80-9

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Fyn-IN-1 Related Antibodies

Top Publications Citing Use of Products

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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GSK-3 GSK-3α GSK-3β

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nNOS iNOS eNOS

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Description

Fyn-IN-1 (Compound 43) is a selective, blood-brain barrier permeable Fyn and GSK-3β inhibitor with IC50 values of 0.044 μM and 0.61 μM, respectively. Fyn-IN-1 significantly downregulates the pro-inflammatory enzyme iNOS. Fyn-IN-1 can be used in the research of neurodegenerative diseases[1].

IC50 & Target[1]

GSK-3β

0.61 μM (IC50)

iNOS

 

Fyn

0.044 μM (IC50)

Molecular Weight

355.84

Formula

C17H14ClN5S
CAS No.
SMILES

CC1=C(N=C(NCC2=CC=NC(Cl)=C2)S1)C3=CNC4=NC=CC=C43
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fyn-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fyn-IN-13107638-80-9SrcGSK-3NO SynthaseGlycogen synthase kinase-3Glycogen synthase kinase 3Nitric oxide synthasesNOSneurodegenerative diseasesInhibitorinhibitorinhibit

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