SH2D3C - SH2 domain containing 3C Gene

Also Known as CHAT; NSP3; SHEP1; PRO34088

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10044

About SH2D3C

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,738,317-127,778,666 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in spleen (RPKM 12.4), lung (RPKM 10.5) and 22 other tissues.

Summary

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SH2D3C Products (7)

mRNA	Protein	Name
NM_001142531.1	NP_001136003.1	SH2 domain-containing protein 3C isoform c
NM_001142532.1	NP_001136004.1	SH2 domain-containing protein 3C isoform c
NM_001142533.1	NP_001136005.1	SH2 domain-containing protein 3C isoform d
NM_001142534.1	NP_001136006.1	SH2 domain-containing protein 3C isoform e
NM_001252334.2	NP_001239263.1	SH2 domain-containing protein 3C isoform f
NM_005489.4	NP_005480.2	SH2 domain-containing protein 3C isoform b
NM_170600.3	NP_733745.1	SH2 domain-containing protein 3C isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22081014	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D3C Protein Structure

SH2

RasGEF

0
200
400
600
800
860 a.a.

Protein Preferred Names	Protein Names
SH2 domain-containing protein 3C	SH2 domain-containing Eph receptor-binding protein 1

SH2D3C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SH2D3C	Q8N5H7	MET	Homo sapiens	P08581	FPS	24728074
Intra	SH2D3C	Q8N5H7	KIT	Homo sapiens	P10721	FPS	24728074

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Eastern Equine Encephalitis	Eee Neuroinvasive Eastern Equine Encephalitis Virus Infection Eastern Equine Encephalomyelitis Encephalomyelitis, Eastern Equine Triple E Eastern Equine Encephalitis Virus Infection Neuroinvasive Eastern Equine Encephalitis Virus Disease Eee - [Eastern Equine Encephalitis]
Western Equine Encephalitis	Western Equine Encephalomyelitis Wee Encephalomyelitis, Western Equine Western Equine Encephalitis Virus Infection Wee - [Western Equine Encephalitis] Western Equine Encephalitis Virus
Blue Toe Syndrome
Noonan Syndrome 12	NS12
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Ross River Fever	Ross River Virus Disease Ross River Virus Infection
Noonan Syndrome 7	NS7 Noonan Syndrome, Type 7
Acute Diarrhea
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Griscelli Syndrome, Type 3	Griscelli Syndrome Type 3 GS3 Griscelli-Prunieras Syndrome Type 3 Hypomelanosis With No Immunologic Or Neurologic Manifestations Griscelli Syndrome 3
Coronavirus Infectious Disease
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12824	SH2D3C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SH2D3C	MGD	MGI:1351631
Macaca mulatta	SH2D3C	VGNC	VGNC:77253
Rattus norvegicus	SH2D3C	RGD	RGD:1307287
Bos taurus	SH2D3C	VGNC	VGNC:34559
Canis familiaris	SH2D3C	VGNC	VGNC:46113
Felis catus	SH2D3C	VGNC	VGNC:65094
Others	SH2D3C	NCBI