BCAR1 Antibody (YA2560)
(Synonyms: BCAR 1; CAS; CAS1; Cass1; CRKAS; p130cas)BCAR1 Antibody (YA2560) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BCAR1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
BCAR1 Antibody (YA2560) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BCAR1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 130 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 93 kDa
Entrez Gene: 9564 Human ; 12927 Mouse ;
SwissProt: P56945 Human ; Q61140 Mouse ; Q63767 Ra
OMIM: 602941 Human
A synthesized peptide derived from human BCAR1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BCAR1 is a Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling[1][2][3].
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Subcellular Localization
Cell junction, focal adhesion; Cytoplasm; Cell projection, axon
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Expression
Tissue_specificity:Expressed in B-cells (at protein level) (PubMed:9020138) . Widely expressed with an abundant expression in the testis (PubMed:10639512) . Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512) -
Isoforms & Post-Translational Modification
P56945 has 8 isomers: P56945-1: 93372 Da (predicted); P56945-2: 95469 Da (predicted); P56945-3: 95454 Da (predicted); P56945-4: 77731 Da (predicted); P56945-5: 93137 Da (predicted); P56945-6: 97877 Da (predicted); P56945-7: 95216 Da (predicted); P56945-8: 93291 Da (predicted).
PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix;Dephosphorylated by PTPN14 at Tyr-128;Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway -
Subunit
Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase (PubMed:9020138). Heterodimerizes with NEDD9 (PubMed:10502414). Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (PubMed:12432078).
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SwissProt ID
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Synonyms
BCAR 1; CAS; CAS1; Cass1; CRKAS; p130cas
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Research Field
Signal Transduction
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