CHN2 - chimerin 2 Gene

Also Known as BCH; CHN2-3; ARHGAP3; RHOGAP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1124

About CHN2

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:29,146,591-29,514,328 (from NCBI)

This gene has 30 transcripts (splice variants), 223 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 21.4), small intestine (RPKM 16.7) and 20 other tissues.

Summary

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

CHN2 Products (14)

mRNA Protein Name
NM_001039936.3 NP_001035025.1 beta-chimaerin isoform 1
NM_001293070.2 NP_001279999.1 beta-chimaerin isoform 4
NM_001293071.2 NP_001280000.1 beta-chimaerin isoform 5
NM_001293072.2 NP_001280001.1 beta-chimaerin isoform 6
NM_001293073.2 NP_001280002.1 beta-chimaerin isoform 7
NM_001293075.2 NP_001280004.1 beta-chimaerin isoform 8
NM_001293076.2 NP_001280005.1 beta-chimaerin isoform 9
NM_001293077.2 NP_001280006.1 beta-chimaerin isoform 10
NM_001293078.2 NP_001280007.1 beta-chimaerin isoform 11
NM_001293079.2 NP_001280008.1 beta-chimaerin isoform 12
NM_001293080.2 NP_001280009.1 beta-chimaerin isoform 13
NM_001293081.2 NP_001280010.1 beta-chimaerin isoform 14
NM_001398427.1 NP_001385356.1 beta-chimaerin isoform 15
NM_004067.4 NP_004058.1 beta-chimaerin isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
8175705 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16628218 GOA
Cellular Component GO Annotation Evidence References Source
located in synapse IDA
IDA: Inferred from direct assay
8175705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHN2 Protein Structure

SH2

SH2: SH2 domain (60 - 128)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (215 - 266)

RhoGAP

RhoGAP: RhoGAP domain (291 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

beta-chimaerin

  • beta-chimerin

CHN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHN2 P52757 SENP8 Homo sapiens Q96LD8
Validated Y2H
32296183
Intra
CHN2 P52757 SENP8 Homo sapiens Q96LD8
Y2H Prey Pooling
32296183
Intra
CHN2 P52757 SENP8 Homo sapiens Q96LD8
Y2H Array
32296183
Intra
CHN2 P52757 ANKK1 Homo sapiens Q8NFD2
Validated Y2H
32296183
Intra
CHN2 P52757 SHF Homo sapiens Q8N9I8
Y2H Array
32296183
Intra
CHN2 P52757 SHF Homo sapiens Q8N9I8
Y2H Prey Pooling
32296183
Intra
CHN2 P52757 SHF Homo sapiens Q8N9I8
Validated Y2H
32296183
Intra
CHN2 P52757 NCK1 Homo sapiens P16333
Y2H Array
32296183
Intra
CHN2 P52757 NCK1 Homo sapiens P16333
Y2H Prey Pooling
32296183
Intra
CHN2 P52757 RAC1 Homo sapiens P63000
FRET
16628218
Intra
CHN2 P52757 RAC1 Homo sapiens P63000
Pull Down
16628218
Intra
CHN2 P52757 RAC1 Homo sapiens P63000
Anti Tag CoIP
16628218
Intra
CHN2 P52757 RAC1 Homo sapiens P63000
Imaging
16628218
Intra
CHN2 P52757 NCK2 Homo sapiens O43639
Y2H Array
32296183
Intra
CHN2 P52757 NCK2 Homo sapiens O43639
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Duodenum Adenocarcinoma

  • Duodenal Adenocarcinoma
Hypertrophic Neuropathy Of Dejerine-Sottas

  • Dejerine-Sottas Disease

  • Dejerine-Sottas Syndrome

  • Charcot-Marie-Tooth Disease Type 3

  • DSS

  • Hereditary Motor And Sensory Neuropathy Type Iii

  • Hmsn3

  • Dejerine-Sottas Neuropathy

  • Hmsn Iii

  • Charcot-Marie-Tooth Disease, Type 3

  • Cmt3

  • Dsn

  • Hmsn 3

  • Hereditary Motor And Sensory Neuropathy Type 3

  • Hereditary Motor And Sensory Neuropathy 3

  • Hypertrophic Neuropathy Of Infancy

  • Charcot-Marie-Tooth Disease Demyelinating Type 4f

  • Charcot-Marie-Tooth Disease Type 4f

  • Charcot-Marie-Tooth Neuropathy Type 4f

  • Cmt4f

  • Hereditary Motor And Sensory Neuropathy Iii

  • Charcot-Marie-Tooth Disease, Demyelinating, Type 4f
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108137 Z-LVG-CHN2 Inhibitor 99.88% Unkown
HY-P5898 Z-Val-Val-Nle-diazomethylketone Inhibitor / Unkown
HY-108137A Z-L(D-Val)G-CHN2 Inhibitor 99.35% Unkown
HY-RS02650 CHN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08633 MPZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22119 Chn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28641 Chn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHN2 VGNC VGNC:49738
Felis catus CHN2 VGNC VGNC:69373
Mus musculus CHN2 MGD MGI:1917243
Bos taurus CHN2 VGNC VGNC:50060
Rattus norvegicus CHN2 RGD RGD:620140
Macaca mulatta CHN2 VGNC VGNC:80861
Others CHN2 NCBI