ANKK1 - ankyrin repeat and kinase domain containing 1 Gene

Also Known as PKK2; sgK288

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 255239

About ANKK1

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,387,779-113,400,416 (from NCBI)

This gene has 2 transcripts (splice variants), 155 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]

ANKK1 Products (1)

mRNA	Protein	Name
NM_178510.2	NP_848605.1	ankyrin repeat and protein kinase domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within regulation of cell cycle process	IDA IDA: Inferred from direct assay	27166167	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	27166167	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANKK1 Protein Structure

Pkinase_Tyr

Ank_2

Ank

Ank_2

Ank

0
200
400
600
765 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and protein kinase domain-containing protein 1	X-kinase

ANKK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ANKK1	Q8NFD2	C12orf57	Homo sapiens	Q99622	Validated Y2H	32296183
Intra	ANKK1	Q8NFD2	C12orf57	Homo sapiens	Q99622	Y2H Prey Pooling	32296183
Intra	ANKK1	Q8NFD2	C12orf57	Homo sapiens	Q99622	Y2H Array	32296183
Intra	ANKK1	Q8NFD2	YEATS4	Homo sapiens	O95619	Y2H Array	32296183
Intra	ANKK1	Q8NFD2	YEATS4	Homo sapiens	O95619	Pull Down	32707033
Intra	ANKK1	Q8NFD2	YEATS4	Homo sapiens	O95619	Y2H Prey Pooling	32296183
Intra	ANKK1	Q8NFD2	CHN2	Homo sapiens	P52757	Y2H Prey Pooling	32296183
Intra	ANKK1	Q8NFD2	CHN2	Homo sapiens	P52757	Y2H Array	32296183
Intra	ANKK1	Q8NFD2	CHN1	Homo sapiens	P15882	Y2H Prey Pooling	32296183
Intra	ANKK1	Q8NFD2	CHN1	Homo sapiens	P15882	Y2H Array	32296183
Intra	ANKK1	Q8NFD2	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	33961781
Intra	ANKK1	Q8NFD2	HIF1AN	Homo sapiens	Q9NWT6	Validated Y2H	32296183
Intra	ANKK1	Q8NFD2	HIF1AN	Homo sapiens	Q9NWT6	Y2H Array	32296183
Intra	ANKK1	Q8NFD2	HIF1AN	Homo sapiens	Q9NWT6	Pull Down	32707033
Intra	ANKK1	Q8NFD2	HIF1AN	Homo sapiens	Q9NWT6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Heroin Dependence
Drug Dependence
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Neuroleptic Malignant Syndrome
Pyromania	Firesetting Behavior Pathological Firesetting Pathological Fire-Setting
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Kleptomania	Pathological Stealing
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Alexithymia
Chromosome 17q23.1-Q23.2 Deletion Syndrome	17q23.1q23.2 Microdeletion Syndrome 17q23.1-Q23.2 Microdeletion Syndrome Del(17)(Q23.1q23.2) Monosomy 17q23.1q23.2 Monosomy 17q23.1-Q23.2
Opiate Dependence	Opioid Dependence Opioid Addiction Opiate Addiction Opioid Type Dependence Opioid-Related Disorders Opium Dependence Narcotic Dependence Intravenous Narcotism Narcotism Nos Oral Narcotism Nos
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Substance Dependence
Premenstrual Tension	Premenstrual Syndrome Pmt - [Premenstrual Tension] Premenstrual Tension Nos Syndrome Of Menstruation
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Cannabis Dependence	Marijuana Abuse Cannabinoid Addiction Cannabinoid Dependence Cannabis Addiction
Hallucinogen Dependence	Hallucinogen Addiction
Cocaine Dependence
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Cannabis Abuse	Marijuana Abuse
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00708	ANKK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANKK1	MGD	MGI:3045301
Canis familiaris	ANKK1	VGNC	VGNC:37874
Rattus norvegicus	ANKK1	RGD	RGD:1305538
Bos taurus	ANKK1	VGNC	VGNC:54855
Felis catus	ANKK1	VGNC	VGNC:102736
Others	ANKK1	NCBI