1. Metabolic Enzyme/Protease
    Anti-infection
  2. Cathepsin
    HSV
    SARS-CoV
  3. Z-LVG-CHN2

Z-LVG-CHN2 

Cat. No.: HY-108137
Handling Instructions

Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.

For research use only. We do not sell to patients.

Z-LVG-CHN2 Chemical Structure

Z-LVG-CHN2 Chemical Structure

CAS No. : 119670-30-3

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Description

Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3].

IC50 & Target

EC50: 190 nM (SAR-COV-2)[3]

In Vitro

Z-LVG-CHN2 (0-10 μM; pre-treated for 16 h) inhibits antiviral activities in a discernable dose-dependent manner in Vero E6 cells by designed to capture multicycle replication, exhibiting an EC50 value of 0.19 μM[1]/

Cell Viability Assay[3]

Cell Line: Vero E6 cells
Concentration: 0.001 μM, 0.003 μM, 0.1 μM, 0.3 μM, 1 μM, 2.5 μM
Incubation Time: Pre-treated for 16 h and then cultured for 24 hours
Result: Inhibited SARS-COV-2 virus replication in a dose-dependent manner.
Molecular Weight

445.51

Formula

C₂₂H₃₁N₅O₅

CAS No.

119670-30-3

SMILES

CC(C)[[email protected]@H](C(N)=O)N(C([[email protected]](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)CC(C=[N+]=[N-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Z-LVG-CHN2CathepsinHSVSARS-CoVHerpes simplex virusSARS coronaviruscysteine proteinaseSAR-COV-23CL pro proteasemimicInhibitorinhibitorinhibit

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Z-LVG-CHN2
Cat. No.:
HY-108137
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