Z-LVG-CHN2 (Standard)
Z-LVG-CHN2 (Standard) is the analytical standard of Z-LVG-CHN2 (HY-108137). This product is intended for research and analytical applications. Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
For research use only. We do not sell to patients.
- CAS No.: 119670-30-3
- Formula: C22H31N5O5
- Molecular Weight:445.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
EC50: 190 nM (SAR-COV-2)[3]
Chemical Information
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CAS No. 119670-30-3
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Molecular Weight 445.51
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Formula C22H31N5O5
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SMILES
[N-]=[N+]=CC(CNC([C@H](C(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. R L Mellgren, et al. Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp Cell Res. 1994 Nov;215(1):164-71. [Content Brief]
[2]. L Björck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus. J Virol [Content Brief]
[3]. Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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