TXK - TXK tyrosine kinase Gene

Homo sapiens

Also known as RLK; TKL; BTKL; PTK4; PSCTK5

Gene ID: 7294 | Gene type: protein coding

About TXK

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:48,066,393-48,134,250 (from NCBI)

This gene has 6 transcripts (splice variants), 117 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TXK Products(1)

mRNA	Protein	Name
NM_003328.3	NP_003319.2	tyrosine-protein kinase TXK

TXK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
527 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase TXK

PTK4 protein tyrosine kinase 4

Related Diseases

Diseases

Alias

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia	XLA
Bruton Type Agammaglobulinemia	Bruton'S Agammaglobulinemia
Bruton-Type Agammaglobulinemia	Agmx1
Imd1	Agammaglobulinemia, X-Linked 1
Btk-Deficiency	Agammaglobulinemia
Hypogammaglobulinemia	Agammaglobulinemia, X-Linked, Type 1
Immunodeficiency 1	Bruton Agammaglobulinemia Tyrosine Kinase Deficiency
Bruton Disease	Bruton'S Agammaglobulinaemia
Bruton'S Sex-Linked Agammaglobulinemia	Bruton'S Type Agammaglobulinemia
Btk Deficiency	Agammaglobulinemia, Btk
Agammaglobulinemia, Bruton Tyrosine Kinase	Congenital Agammaglobulinemia
Immunodeficiency Type 1	X-Linked Agammaglobulinemia Type 1

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10644	Lck inhibitor 2	Inhibitor	99.81%	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-RS15285	TXK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TXK	VGNC	VGNC:48005
Bos taurus	TXK	VGNC	VGNC:36529
Mus musculus	TXK	MGD	MGI:102960
Felis catus	TXK	VGNC	VGNC:66719
Macaca mulatta	TXK	VGNC	VGNC:78678
Rattus norvegicus	TXK	RGD	RGD:1306481
Others	TXK	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.