DOK2 - docking protein 2 Gene

Also Known as p56DOK; p56dok-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9046

About DOK2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:21,908,873-21,913,690 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 7 paralogues. Broad expression in spleen (RPKM 18.2), lung (RPKM 14.7) and 18 other tissues.

Summary

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

DOK2 Products (4)

mRNA Protein Name
NM_001317800.2 NP_001304729.1 docking protein 2 isoform b
NM_001401272.1 NP_001388201.1 docking protein 2 isoform c
NM_003974.4 NP_003965.2 docking protein 2 isoform a
NM_201349.3 NP_958728.1 docking protein 2 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK2 Protein Structure

IRS

IRS: PTB domain (IRS-1 type) (149 - 246)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
Protein Preferred Names Protein Names

docking protein 2

  • docking protein 2, 56kD

DOK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DOK2 O60496 YES1 Homo sapiens P07947
Validated Y2H
32296183
Intra
DOK2 O60496 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Intra
DOK2 O60496 TXK Homo sapiens P42681
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Histiocytic And Dendritic Cell Cancer

  • Histiocytic And Dendritic Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03934 DOK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992162 23ME-00610 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DOK2 VGNC VGNC:61581
Mus musculus DOK2 MGD MGI:1332623
Bos taurus DOK2 VGNC VGNC:28166
Macaca mulatta DOK2 VGNC VGNC:71969
Canis familiaris DOK2 VGNC VGNC:40056
Rattus norvegicus DOK2 RGD RGD:1310966
Others DOK2 NCBI