DOK2 - docking protein 2 Gene

Homo sapiens

Also known as p56DOK; p56dok-2

Gene ID: 9046 | Gene type: protein coding

About DOK2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:21,908,873-21,913,690 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 7 paralogues. Broad expression in spleen (RPKM 18.2), lung (RPKM 14.7) and 18 other tissues.

Summary

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

DOK2 Products(4)

mRNA	Protein	Name
NM_001317800.2	NP_001304729.1	docking protein 2 isoform b
NM_001401272.1	NP_001388201.1	docking protein 2 isoform c
NM_003974.4	NP_003965.2	docking protein 2 isoform a
NM_201349.3	NP_958728.1	docking protein 2 isoform b

DOK2 Protein Structure

IRS

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

docking protein 2

docking protein 2, 56kD

Related Diseases

Diseases

Alias

Histiocytic And Dendritic Cell Cancer

Histiocytic And Dendritic Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03934	DOK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DOK2	VGNC	VGNC:61581
Mus musculus	DOK2	MGD	MGI:1332623
Bos taurus	DOK2	VGNC	VGNC:28166
Macaca mulatta	DOK2	VGNC	VGNC:71969
Canis familiaris	DOK2	VGNC	VGNC:40056
Rattus norvegicus	DOK2	RGD	RGD:1310966