SORBS2 - sorbin and SH3 domain containing 2 Gene

Also Known as ARGBP2; PRO0618

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8470

About SORBS2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:185,585,523-185,956,372 (from NCBI)

This gene has 73 transcripts (splice variants), 207 orthologues and 12 paralogues. Broad expression in heart (RPKM 46.6), adrenal (RPKM 26.3) and 19 other tissues.

Summary

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin Cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SORBS2 Products (42)

mRNA Protein Name
NM_001145670.2 NP_001139142.1 sorbin and SH3 domain-containing protein 2 isoform 3
NM_001145671.3 NP_001139143.1 sorbin and SH3 domain-containing protein 2 isoform 4
NM_001145672.2 NP_001139144.1 sorbin and SH3 domain-containing protein 2 isoform 5
NM_001145673.3 NP_001139145.1 sorbin and SH3 domain-containing protein 2 isoform 6
NM_001145674.3 NP_001139146.1 sorbin and SH3 domain-containing protein 2 isoform 7
NM_001145675.3 NP_001139147.1 sorbin and SH3 domain-containing protein 2 isoform 8
NM_001270771.3 NP_001257700.1 sorbin and SH3 domain-containing protein 2 isoform 9
NM_001394245.1 NP_001381174.1 sorbin and SH3 domain-containing protein 2 isoform 10
NM_001394246.1 NP_001381175.1 sorbin and SH3 domain-containing protein 2 isoform 11
NM_001394247.1 NP_001381176.1 sorbin and SH3 domain-containing protein 2 isoform 11
NM_001394248.1 NP_001381177.1 sorbin and SH3 domain-containing protein 2 isoform 12
NM_001394249.1 NP_001381178.1 sorbin and SH3 domain-containing protein 2 isoform 12
NM_001394250.1 NP_001381179.1 sorbin and SH3 domain-containing protein 2 isoform 13
NM_001394251.1 NP_001381180.1 sorbin and SH3 domain-containing protein 2 isoform 9
NM_001394252.1 NP_001381181.1 sorbin and SH3 domain-containing protein 2 isoform 9
NM_001394253.1 NP_001381182.1 sorbin and SH3 domain-containing protein 2 isoform 9
NM_001394254.1 NP_001381183.1 sorbin and SH3 domain-containing protein 2 isoform 14
NM_001394255.1 NP_001381184.1 sorbin and SH3 domain-containing protein 2 isoform 15
NM_001394256.1 NP_001381185.1 sorbin and SH3 domain-containing protein 2 isoform 15
NM_001394257.1 NP_001381186.1 sorbin and SH3 domain-containing protein 2 isoform 15
NM_001394258.1 NP_001381187.1 sorbin and SH3 domain-containing protein 2 isoform 16
NM_001394259.1 NP_001381188.1 sorbin and SH3 domain-containing protein 2 isoform 17
NM_001394260.1 NP_001381189.1 sorbin and SH3 domain-containing protein 2 isoform 17
NM_001394261.1 NP_001381190.1 sorbin and SH3 domain-containing protein 2 isoform 18
NM_001394262.1 NP_001381191.1 sorbin and SH3 domain-containing protein 2 isoform 19
NM_001394263.1 NP_001381192.1 sorbin and SH3 domain-containing protein 2 isoform 19
NM_001394264.1 NP_001381193.1 sorbin and SH3 domain-containing protein 2 isoform 20
NM_001394265.1 NP_001381194.1 sorbin and SH3 domain-containing protein 2 isoform 21
NM_001394266.1 NP_001381195.1 sorbin and SH3 domain-containing protein 2 isoform 2
NM_001394267.1 NP_001381196.1 sorbin and SH3 domain-containing protein 2 isoform 2
NM_001394268.1 NP_001381197.1 sorbin and SH3 domain-containing protein 2 isoform 2
NM_001394270.1 NP_001381199.1 sorbin and SH3 domain-containing protein 2 isoform 2
NM_001394271.1 NP_001381200.1 sorbin and SH3 domain-containing protein 2 isoform 2
NM_001394272.1 NP_001381201.1 sorbin and SH3 domain-containing protein 2 isoform 2
NM_001394273.1 NP_001381202.1 sorbin and SH3 domain-containing protein 2 isoform 22
NM_001394274.1 NP_001381203.1 sorbin and SH3 domain-containing protein 2 isoform 23
NM_001394275.1 NP_001381204.1 sorbin and SH3 domain-containing protein 2 isoform 23
NM_001394276.1 NP_001381205.1 sorbin and SH3 domain-containing protein 2 isoform 24
NM_001394277.1 NP_001381206.1 sorbin and SH3 domain-containing protein 2 isoform 25
NM_001395207.1 NP_001382136.1 sorbin and SH3 domain-containing protein 2 isoform 26
NM_003603.7 NP_003594.3 sorbin and SH3 domain-containing protein 2 isoform 1
NM_021069.6 NP_066547.1 sorbin and SH3 domain-containing protein 2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SORBS2 Protein Structure

Sorb

Sorb: Sorbin homologous domain (67 - 116)

SH3_1

SH3_1: SH3 domain (869 - 913)

SH3_1

SH3_1: SH3 domain (944 - 991)

SH3_9

SH3_9: Variant SH3 domain (1048 - 1098)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1100 a.a.
Protein Preferred Names Protein Names

sorbin and SH3 domain-containing protein 2

  • Arg binding protein 2

SORBS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SORBS2 O94875 HEL2 Homo sapiens V9HW98
Y2H Array
25416956
Intra
SORBS2 O94875 SH2D4A Homo sapiens Q9H788-2
Y2H Prey Pooling
25416956
Intra
SORBS2 O94875 SH2D4A Homo sapiens Q9H788-2
Validated Y2H
25416956
Intra
SORBS2 O94875 SH2D4A Homo sapiens Q9H788-2
Y2H Array
25416956
Intra
SORBS2 O94875 PAK2 Homo sapiens Q13177
Filter Binding
16374509
Intra
SORBS2 O94875 PAK2 Homo sapiens Q13177
Phage Display
16374509
Intra
SORBS2 O94875 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
25416956
Intra
SORBS2 O94875 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
25416956
Intra
SORBS2 O94875 VPS37C Homo sapiens A5D8V6
Y2H Array
25416956
Intra
SORBS2 O94875 PALLD Homo sapiens Q8WX93
Y2H
16125169
Intra
SORBS2 O94875 PALLD Homo sapiens Q8WX93
Pull Down
16125169
Intra
SORBS2 O94875 WAS Homo sapiens P42768
Validated Y2H
25416956
Intra
SORBS2 O94875 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
SORBS2 O94875 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
SORBS2 O94875 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Intra
SORBS2 O94875 EFS Homo sapiens O43281
Validated Y2H
25416956
Cross
SORBS2 O94875 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
Cross
SORBS2 O94875 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Y2H Prey Pooling
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypotrichosis 13

  • HYPT13

  • Hypotrichosis With Woolly Hair

  • Hypotrichosis, Type 13
Retinitis Pigmentosa 23

  • RP23

  • Retinitis Pigmentosa-23

  • Retinitis Pigmentosa, Type 23

  • Rp23 Gene
Facioscapulohumeral Muscular Dystrophy 1

  • Facioscapulohumeral Muscular Dystrophy

  • Fshd

  • Landouzy-Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Facioscapulohumeral

  • FSHD1

  • Fshd1a

  • Muscular Dystrophy, Facioscapulohumeral, Type 1a

  • Facioscapulohumeral Muscular Dystrophy Type 1a

  • Fsh Muscular Dystrophy

  • Facioscapulohumeral Muscular Dystrophy 1a

  • Facioscapulohumeral Atrophy

  • Facioscapulohumeral Myopathy

  • Muscular Dystrophy, Facioscapulohumeral, Type 1

  • Facioscapulohumeral Muscular Dystrophy Type 1

  • Landouzy Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Landouzy-Dejerine

  • Fshmd1a

  • Facio-Scapulo-Humeral Dystrophy

  • Facioscapulohumeral Type Progressive Muscular Dystrophy

  • Facioscapuloperoneal Muscular Dystrophy

  • Facioscapulohumeral Dystrophy

  • Fsh Dystrophy

  • Landouzy-Dejerine Dystrophy

  • Landouzy-Dejerine Myopathy

  • Fmd

  • Facioscapulohumeral Muscular Dystrophy-1a

  • Muscular Dystrophy Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral, Type 1

  • Landouzy-Dejerine Disease

  • Landouzy-Déjerine Atrophy

  • Facioscapulohumeral Muscle Dystrophy

  • Fmd - [Facioscapulohumeral Muscular Dystrophy]

  • Fsh - [Facioscapulohumeral Muscular Dystrophy]

  • Fshd - [Facioscapulohumeral Muscular Dystrophy]

  • Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

  • Landouzy-Déjérine Muscular Dystrophy
Myopathy, Spheroid Body

  • Spheroid Body Myopathy

  • Autosomal Dominant Spheroid Body Myopathy

  • SBM
Left Ventricular Noncompaction

  • Noncompaction Cardiomyopathy

  • Left Ventricular Hypertrabeculation

  • Lvnc

  • Spongy Myocardium

  • Isolated Noncompaction Of The Ventricular Myocardium

  • Left Ventricular Myocardial Noncompaction Cardiomyopathy

  • Fetal Myocardium

  • Honeycomb Myocardium

  • Hypertrabeculation Syndrome

  • Left Ventricular Non-Compaction

  • Lvht

  • Non-Compaction Of The Left Ventricular Myocardium

  • Ventricular Noncompaction, Left

  • Non-Compaction Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13568 SORBS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21941 Sorbs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28458 Sorbs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SORBS2 VGNC VGNC:106942
Felis catus SORBS2 VGNC VGNC:80007
Macaca mulatta SORBS2 VGNC VGNC:77767
Canis familiaris SORBS2 VGNC VGNC:51827
Mus musculus SORBS2 MGD MGI:1924574
Rattus norvegicus SORBS2 RGD RGD:620061
Others SORBS2 NCBI