RHOV - ras homolog family member V Gene

Also Known as CHP; ARHV; WRCH2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 171177

About RHOV

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,872,214-40,874,234 (from NCBI)

This gene has 1 transcript (splice variant), 241 orthologues and 22 paralogues. Biased expression in esophagus (RPKM 34.6), skin (RPKM 27.2) and 5 other tissues.

Summary

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; cell projection assembly; and endocytosis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHOV Products (1)

mRNA	Protein	Name
NM_133639.4	NP_598378.3	rho-related GTP-binding protein RhoV

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16752908	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOV Protein Structure

Ras

0
100
200
236 a.a.

Protein Preferred Names	Protein Names
rho-related GTP-binding protein RhoV	CDC42-like GTPase 2

RHOV Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHOV	Q96L33	PAK6	Homo sapiens	Q9NQU5	Validated Y2H	32296183
Intra	RHOV	Q96L33	NCK2	Homo sapiens	O43639	ITC	16752908
Intra	RHOV	Q96L33	NCK2	Homo sapiens	O43639	NMR	16752908

Cross: Cross-species interaction Intra: Intraspecies interaction

RHOV Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810089	Rho V Antibody (YA9433)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Ascaridiasis	Ascariasis
Toxic Megacolon	Megacolon, Toxic Toxic Dilatation Of Colon Toxic Functional Megacolon
Deafness, Autosomal Recessive 104	DFNB104 Autosomal Recessive Nonsyndromic Deafness 104 Autosomal Recessive Deafness 104 Deafness, Autosomal Recessive, 104 Deafness, Autosomal Recessive, Type 104
Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia	Konigsmark Syndrome DFNA1 Autosomal Dominant Nonsyndromic Deafness 1 Lfhl1 Deafness, Autosomal Dominant 1 Autosomal Dominant Deafness 1 Autosomal Dominant Deafness 1, With Or Without Thrombocytopenia Hereditary Low Frequency Hearing Loss 1 Diaph1-Related Sensorineural Hearing Loss-Thrombocytopenia Syndrome Diaph1-Related Sensorineural Deafness-Thrombocytopenia Syndrome Hereditary Low-Frequency Hearing Loss Hereditary Low-Frequency Sensorineural Hearing Loss Lfsnhl1 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 1 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 1 Deafness, Autosomal Dominant, Type 1
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11960	RHOV Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RHOV	VGNC	VGNC:55140
Mus musculus	RHOV	MGD	MGI:2444227
Rattus norvegicus	RHOV	RGD	RGD:628824
Canis familiaris	RHOV	VGNC	VGNC:45566
Felis catus	RHOV	VGNC	VGNC:64619
Others	RHOV	NCBI