SCX - scleraxis bHLH transcription factor Gene

Also Known as SCXA; SCXB; bHLHa48

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 642658

About SCX

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,266,453-144,268,481 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 1.6), prostate (RPKM 1.6) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SCX Products (1)

mRNA	Protein	Name
NM_001080514.3	NP_001073983.1	basic helix-loop-helix transcription factor scleraxis

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10775504	GOA
contributes to E-box binding	IDA IDA: Inferred from direct assay	10775504	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	10775504	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10775504	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10775504	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	10775504	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
basic helix-loop-helix transcription factor scleraxis	class A basic helix-loop-helix protein 41

SCX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCX	Q7RTU7	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	SCX	Q7RTU7	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	SCX	Q7RTU7	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	SCX	Q7RTU7	MYF5	Homo sapiens	P13349	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Calcific Tendinitis	Calcific Tendinitis Nos
Anomalous Left Coronary Artery From The Pulmonary Artery	Bland White Garland Syndrome Alcapa Bland-White-Garland Syndrome White-Garland Syndrome
Acromesomelic Dysplasia 2a	Chondrodysplasia, Grebe Type Acromesomelic Dysplasia, Grebe Type Grebe Chondrodysplasia Amdg Grebe Syndrome AMD2A Grebe Dysplasia Achondrogenesis, Brazilian Achondrogenesis, Type Ii, Formerly Acromesomelic Dysplasia-2a Achondrogenesis Type Ii Brazilian Achondrogenesis Acromesomelic Chondrodysplasia, Grebe Type
Tendinitis	Tendinopathy
Cleft Soft Palate	Cleft Velum Cleft Velum Palatinum Soft Cleft Palate Soft Palate Perforation
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Lacrimoauriculodentodigital Syndrome	Ladd Syndrome Levy-Hollister Syndrome Lacrimo-Auriculo-Dento-Digital Syndrome LADD Lacrimoauriculodento-Digital Syndrome Levy Hollister Syndrome Lard Syndrome Lacrimoauriculoradiodental Syndrome LADDS Congenital Duodenal Obstruction Due To Malrotation Of Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158231	Polyether F127 Diacrylate	Activator	/	Unkown
HY-RS12574	SCX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22084	Scx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28604	Scx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W667933	S-Propyl-L-cysteine sulfoxide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCX	RGD	RGD:1588254
Bos taurus	SCX	VGNC	VGNC:58408
Mus musculus	SCX	MGD	MGI:102934
Macaca mulatta	SCX	VGNC	VGNC:84112
Others	SCX	NCBI