2. Cytoskeleton Protein Tyrosine Kinase/RTK
  3. Integrin FAK
  4. Polyether F127 Diacrylate

Polyether F127 Diacrylate (F127DA) is an acrylated polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer. Polyether F127 Diacrylate rapidly crosslinks and cures into a gel under ultraviolet or visible light with the action of a photoinitiator. Polyether F127 Diacrylate exhibits excellent thermogelation properties and favorable biosafety. Polyether F127 Diacrylate can upregulate the Integrin-FAK pathway, enhance collagen production, increase the protein and gene expression levels of COL-1/SCX, and promote fibroblastic differentiation of periodontal ligament stem cells. Polyether F127 Diacrylate promotes periodontal ligament regeneration and reduces abnormal healing in a rat model of delayed replanted teeth. Polyether F127 Diacrylate promotes functional osteochondral regeneration in a rat model of osteoarthritis. Polyether F127 Diacrylate supports adipose tissue survival, rendering it suitable for breast reconstruction applications. Polyether F127 Diacrylate can be used in studies related to periodontal ligament injury, breast defect and osteoarthritis.

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Polyether F127 Diacrylate

Polyether F127 Diacrylate Chemical Structure

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Polyether F127 Diacrylate Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Polyether F127 Diacrylate (F127DA) is an acrylated polyethylene glycol-polypropylene glycol-polyethylene glycol triblock copolymer. Polyether F127 Diacrylate rapidly crosslinks and cures into a gel under ultraviolet or visible light with the action of a photoinitiator. Polyether F127 Diacrylate exhibits excellent thermogelation properties and favorable biosafety. Polyether F127 Diacrylate can upregulate the Integrin-FAK pathway, enhance collagen production, increase the protein and gene expression levels of COL-1/SCX, and promote fibroblastic differentiation of periodontal ligament stem cells. Polyether F127 Diacrylate promotes periodontal ligament regeneration and reduces abnormal healing in a rat model of delayed replanted teeth. Polyether F127 Diacrylate promotes functional osteochondral regeneration in a rat model of osteoarthritis. Polyether F127 Diacrylate supports adipose tissue survival, rendering it suitable for breast reconstruction applications. Polyether F127 Diacrylate can be used in studies related to periodontal ligament injury, breast defect and osteoarthritis[1][2][3].

In Vitro

Polyether F127 Diacrylate (5-20% wt/vol) hydrogel exhibits excellent cytocompatibility with hPDLSCs, maintains high cell viability (>90%) and supports cell proliferation within 7 days, among which F127DA-5 promotes the highest proliferation rate[1].
Hydrogels of Polyether F127 Diacrylate (5-20% wt/vol) exert no differential effect on the fibroblastic differentiation of hPDLSCs under static conditions; however, under mechanical loading conditions (0-120 kPa, 1 Hz, 1 h day-1 for 7 days), F127DA-5 significantly promotes the fibroblastic differentiation of hPDLSCs by upregulating the integrin-FAK pathway and cytoskeleton rearrangement, which is characterized by increased collagen production, elevated protein expression levels of COL-1/SCX, and upregulated gene expression levels of COL-1/SCX[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polyether F127 Diacrylate Related Antibodies

Cell Viability Assay[1]

Cell Line: human periodontal ligament stem cells (hPDLSCs)
Concentration: 5% wt/vol (F127DA-5); 10% wt/vol (F127DA-10); 20% wt/vol (F127DA-20)
Incubation Time: 24 h (morphology); 1, 3, 7 days (viability/proliferation)
Result: Adhered to all F127DA hydrogel surfaces with uniform round/compact morphology, with no significant difference in number of round cells across groups.
Showed >90% cell viability for all groups at 1, 3, 7 days.
Exhibited increasing proliferation over time, with F127DA-5 having significantly higher optical density (OD) values at 450 nm than F127DA-20 on days 3 and 7.

Cell Differentiation Assay[1]

Cell Line: human periodontal ligament stem cells (hPDLSCs)
Concentration: 5% wt/vol (F127DA-5); 10% wt/vol (F127DA-10); 20% wt/vol (F127DA-20); 0-120 kPa (cytomechanical loading pressure)
Incubation Time: 7 days (static culture); 7 days (cytomechanical loading, 1 Hz, 1 h day-1)
Result: Showed no significant differences in collagen concentration, COL-1/SCX immunofluorescence intensity, or COL-1/SCX gene expression across F127DA groups under static conditions.
Exhibited significantly higher collagen concentration, COL-1/SCX immunofluorescence intensity, and COL-1/SCX gene expression in F127DA-5 compared to F127DA-10 and F127DA-20 under cytomechanical loading.
In Vivo

Polyether F127 Diacrylate (5-20% wt/vol; subcutaneous; single implant) exhibits in vivo biocompatibility at 2 weeks after subcutaneous implantation in male C57BL/6 mice, with no systemic toxicity or local adverse tissue reactions. It shows slow in vivo biodegradation while maintaining structural presence at the implantation site for at least 2 weeks[1].
Among Polyether F127 Diacrylate (5-20% wt/vol; local coating on root surfaces; single dose), the F127DA-5 hydrogel significantly promotes periodontal ligament regeneration and reduces abnormal healing (root resorption and ankylosis) in a rat model of delayed tooth replantation[1].
The 3D-printed porous scaffold composed of Polyether F127 Diacrylate (15% (w/v); subcutaneous; single implantation) and 3% PEGDA exhibits excellent in vivo biocompatibility, structural stability, and supportive effects on adipose tissue survival after subcutaneous implantation in nude mice, rendering it suitable for breast reconstruction applications[2].
The composite of Polyether F127 Diacrylate (15% (w/v); intra-articular; single injection; in situ photocrosslinking with 405 nm light) and 10% (w/v) GelMA, loaded with 30 μM KGN and 200 ng/mL TGF-β, significantly promotes functional osteochondral regeneration in a rat osteoarthritis model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 7-8 weeks old)[1]
Dosage: 5%, 10%, 20% wt/vol (F127DA-5, F127DA-10, F127DA-20 hydrogels)
Administration: subcutaneous; single implant
Result: Showed no signs of infection at surgical sites; all animals survived.
Demonstrated immune cell infiltration around implants, no fibrous tissue formation at 2 weeks, and newly formed blood vessels in transplanted areas.
Detected no tissue damage, inflammation, hemorrhage, or necrosis in heart, lung, liver, kidney, or spleen tissues.\nDegraded over time but remained at implantation sites for 2 weeks post-transplantation.
Animal Model: Sprague-Dawley (male, 7-8 weeks old, 180-250 g, periodontal ligament injury model via delayed replantation of avulsed incisor)[1]
Dosage: 5%, 10%, 20% wt/vol (F127DA-5, F127DA-10, F127DA-20 hydrogels; single 20 μL root coating)
Administration: local coating on root surfaces; single dose; prior to replantation
Result: Exhibited the highest area of newly formed PDL tissue in the F127DA-5 group, with significantly greater PDL length and significantly reduced root resorption and ankylosis compared to the F127DA-10 group.
Showed reduced root resorption in the F127DA-20 group compared to the F127DA-10 group.
Formed dense, perpendicular collagen fiber bundles resembling native PDLs between roots and alveolar bone in the F127DA-5 group, with minimal inflammation, root resorption, and ankylosis.
Demonstrated frequent inflammation, replacement root resorption, and ankylosis in the F127DA-10 and F127DA-20 groups.
Showed the highest expression levels of PDL fibrogenic differentiation markers COL-1 and SCX in newly formed tissues in the F127DA-5 group.
Animal Model: nude mice (female, 8 weeks old)[2]
Dosage: 15% (w/v) (formulated with 3% PEGDA, 0.25% LAP, and UV absorber)
Administration: subcutaneous; single implantation
Result: Showed visible blood vessels on scaffold surface by 14 days post-implantation.
Developed an obvious fat mass with no observed foreign body reaction by 28 days post-implantation.
Revealed clearly visible round or multilobular adipose tissue structures within and around the scaffold at both 14 and 28 days via histological HE staining.
Maintained no significant degradation over 28 days, with stable weight, width, and length measurements throughout the observation period.
Exhibited a compression modulus of (17.12) kPa, close to that of commercial breast prostheses and within the range of natural breast tissue (2-66 kPa).
Animal Model: Sprague-Dawley (SD) (8-week-old male; osteoarthritis model via medial meniscus defect + 2 weeks rearing + femur osteochondral defect creation)[3]
Dosage: 15% (w/v) (combined with 10% (w/v) GelMA, loaded with 30 μM KGN and 200 ng/mL TGF-β)
Administration: intra-articular; single injection; in situ photocrosslinking with 405 nm light
Result: Promoted significant functional cartilage regeneration with more intact glycosaminoglycan-rich matrix compared to control groups.
Demonstrated effective repair of osteochondral defect structure, with more organized tissue architecture compared to control groups.
Reached COL II fluorescence intensity of 19.28 a.u., significantly higher than defect and single-drug groups.
Achieved the smoothest subchondral bone surface with the least damage, with coronal plane CT intensity of 147.1, sagittal plane intensity of 133.2, and transversal plane intensity of 156.3, all significantly higher than control groups.
Appearance

Solid

Color

White to off-white

SMILES

[Polyether F127 Diacrylate]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

SDS (251 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References
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Polyether F127 Diacrylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polyether F127 DiacrylateF127DAIntegrinFAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseAcrylated triblock copolymerperiodontal ligament injurybreast defect and osteoarthritishPDLSCsC57BL/6 miceSprague-Dawley Ratnude miceInhibitorinhibitorinhibit

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