NPAS2 - neuronal PAS domain protein 2 Gene

Also Known as MOP4; PASD4; bHLHe9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4862

About NPAS2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:100,818,723-100,996,829 (from NCBI)

This gene has 12 transcripts (splice variants), 143 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 4.7), urinary bladder (RPKM 4.5) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

NPAS2 Products (1)

mRNA Protein Name
NM_002518.4 NP_002509.2 neuronal PAS domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11441146 GOA
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
9079689 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14645221 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
18819933 GOA
involved in positive regulation of DNA repair IMP
IMP: Inferred from mutant phenotype
18819933 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11441146 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18819933 GOA
involved in response to redox state IDA
IDA: Inferred from direct assay
11441146 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14645221 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPAS2 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (10 - 57)

PAS

PAS: PAS fold (85 - 156)

PAS_11

PAS_11: PAS domain (249 - 352)

  • 0
  • 200
  • 400
  • 600
  • 824 a.a.
Protein Preferred Names Protein Names

neuronal PAS domain-containing protein 2

  • PAS domain-containing protein 4

NPAS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NPAS2 Q99743 BMAL1 Homo sapiens O00327-8
Y2H Array
24722188
Intra
NPAS2 Q99743 BMAL1 Homo sapiens O00327-8
Y2H Prey Pooling
32296183
Intra
NPAS2 Q99743 BMAL1 Homo sapiens O00327-8
Y2H Array
32296183
Intra
NPAS2 Q99743 BMAL2 Homo sapiens Q8WYA1-3
Y2H Array
24722188
Intra
NPAS2 Q99743 BMAL2 Homo sapiens Q8WYA1-3
Y2H Prey Pooling
32296183
Intra
NPAS2 Q99743 BMAL2 Homo sapiens Q8WYA1-3
Y2H Array
32296183
Intra
NPAS2 Q99743 BMAL1 Homo sapiens O00327
Anti Tag CoIP
33961781
Intra
NPAS2 Q99743 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
Intra
NPAS2 Q99743 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
Intra
NPAS2 Q99743 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
NPAS2 Q99743 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
NPAS2 Q99743 NCK2 Homo sapiens O43639
Y2H Array
32296183
Intra
NPAS2 Q99743 NCK2 Homo sapiens O43639
Y2H Prey Pooling
32296183
Intra
NPAS2 Q99743 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
NPAS2 Q99743 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra
NPAS2 Q99743 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Delayed Sleep Phase Disorder

  • Delayed Sleep Phase Syndrome

  • Delayed Sleep Phase Syndrome, Susceptibility To

  • DSPD

  • Delayed Sleep Phase Disorder, Susceptibility To

  • DSPS

  • Sleep Phase, Delayed, Disorder

  • Sleep Phase Syndrome, Delayed, Susceptibility To
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Restless Legs Syndrome

  • Wed

  • Willis-Ekbom Disease

  • Restless Leg Syndrome

  • Ekbom Syndrome

  • Wittmaack-Ekbom Syndrome

  • Willis Ekbom Disease

  • Ekbom'S Syndrome

  • Rls

  • Restless Legs

  • Restless Legs Syndrome, Susceptibility To
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09469 NPAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21002 Npas2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27519 Npas2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPAS2 RGD RGD:1309681
Bos taurus NPAS2 VGNC VGNC:32190
Canis familiaris NPAS2 VGNC VGNC:43909
Felis catus NPAS2 VGNC VGNC:68526
Macaca mulatta NPAS2 VGNC VGNC:75378
Mus musculus NPAS2 MGD MGI:109232
Others NPAS2 NCBI