Gemcitabine-13C,15N2 hydrochloride
Based on 1 Customer Validation
Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 2757566-59-7
- Formula: C813CH12ClF2N15N2O4
- Molecular Weight:302.64
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-17026
Gemcitabine
-
HY-138253S
2′,2′-Difluorodeoxyuridine-13C,15N2
-
HY-138253
2′,2′-Difluorodeoxyuridine
-
HY-B0003
Gemcitabine hydrochloride
-
HY-15345A
Tetrahydrouridine
-
HY-13637
Ganciclovir
-
HY-119649S
Flonicamid-15N,18O
-
HY-13637R
Ganciclovir (Standard)
-
HY-13637A
Ganciclovir sodium
-
HY-118122
Fialuridine
-
HY-B0021
Doxifluridine
-
HY-N1584B
Halofuginone hydrochloride
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 2757566-59-7
-
Unlabeled Cas 122111-03-9
-
Appearance Solid
-
Molecular Weight 302.64
-
Formula C813CH12ClF2N15N2O4
-
Color White to off-white
-
SMILES
OC[C@H]([C@@H](O)C1(F)F)O[C@H]1[15N]2C=CC(N)=[15N][13C]2=O.Cl
-
Synonyms
LY 188011-13C,15N2 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 62.5 mg/mL (206.52 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (82.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80 [Content Brief]
[3]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer18(2):198-206 [Content Brief]
[4]. Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2292(22):9136-9149. [Content Brief]
[5]. Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 1713:194. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.3043 mL | 16.5213 mL | 33.0426 mL | 82.6064 mL |
| 5 mM | 0.6609 mL | 3.3043 mL | 6.6085 mL | 16.5213 mL | |
| 10 mM | 0.3304 mL | 1.6521 mL | 3.3043 mL | 8.2606 mL | |
| 15 mM | 0.2203 mL | 1.1014 mL | 2.2028 mL | 5.5071 mL | |
| 20 mM | 0.1652 mL | 0.8261 mL | 1.6521 mL | 4.1303 mL | |
| 25 mM | 0.1322 mL | 0.6609 mL | 1.3217 mL | 3.3043 mL | |
| 30 mM | 0.1101 mL | 0.5507 mL | 1.1014 mL | 2.7535 mL | |
| 40 mM | 0.0826 mL | 0.4130 mL | 0.8261 mL | 2.0652 mL | |
| 50 mM | 0.0661 mL | 0.3304 mL | 0.6609 mL | 1.6521 mL | |
| 60 mM | 0.0551 mL | 0.2754 mL | 0.5507 mL | 1.3768 mL | |
| 80 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL | |
| DMSO | 100 mM | 0.0330 mL | 0.1652 mL | 0.3304 mL | 0.8261 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Gemcitabine-13C,15N2 hydrochloride Related Classifications
HY-B0003S Related Classifications
Powered by Bioz