2757566-59-7
Chemical Structure
Gemcitabine-13C,15N2 hydrochloride
Synonym(s): LY 188011-13C,15N2 hydrochloride
- CAS No.: 2757566-59-7
- Formula:C813CH12ClF2N15N2O4
- Molecular Weight:302.64
IUPAC Name: (E)-N-(5-carbamoyl-1-(4-(6-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamido)-3H-imidazo[4,5-b]pyridin-3-yl)but-2-en-1-yl)-7-(3-hydroxypropoxy-1,1,2,2,3,3-d6)-1H-benzo[d]imidazol-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide
InChIKey: OKKDEIYWILRZIA-ACCKZTSYSA-N
SMILES: OC[C@H]([C@@H](O)C1(F)F)O[C@H]1[15N]2C=CC(N)=[15N][13C]2=O.Cl
Biological Activity: Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gemcitabine-13C,15N2 hydrochloride | 99.55% | Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||||||||||||||||||||
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Gemcitabine hydrochloride (Standard) | 99.94% | Gemcitabine (hydrochloride) (Standard) is the analytical standard of Gemcitabine (hydrochloride). This product is intended for research and analytical applications. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||||||||||||||||||||
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(2S)-Gemcitabine-13C,15N2 hydrochloride | 99.55% | (2S)-Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled (2S)-Gemcitabine hydrochloride. | ||||||||||||||||||||
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Gemcitabine hydrochloride | 99.97% | Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80 [Content Brief]
- [3]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer18(2):198-206 [Content Brief]
