1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Floxuridine (Synonyms: 5-Fluorouracil 2'-deoxyriboside)

Cat. No.: HY-B0097 Purity: 99.93%
Handling Instructions

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.

For research use only. We do not sell to patients.

Floxuridine Chemical Structure

Floxuridine Chemical Structure

CAS No. : 50-91-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg USD 108 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
500 mg USD 240 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
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5 g   Get quote  

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  • Technical Information

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  • References

Description

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. IC50 value: Target: Nucleoside antimetabolite/analog Floxuridine (Fludara) is a prodrug of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1. Floxuridine (Fludara) belongs to the class known as antimetabolites. Floxuridine (Fludara) is most often used in the treatment of colorectal cancer. Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine. Floxuridine (Fludara) works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil [1]. FdUrd induced an immediate increase in tumor uptake of 5-[(125)I]iodo-2'-deoxyuridine, that vanished after 6 h, as also confirmed by flow cytometry. Biodistribution measurements showed that FdUrd pretreatment increased [(18)F]FLT uptake in all tumors by factors of 3.2 to 7.8 compared with controls, while [(18)F]FDG tumor uptake was about fourfold and sixfold lower in breast cancers and lymphoma. Dynamic PET in FdUrd pretreated mice showed that [(18)F]FLT uptake in all tumors increased steadily up to 1.5 h. MRI showed a well-vascularized homogenous lymphoma with high [(18)F]FLT uptake, while in breast cancer, a central necrosis shown by MRI was inactive in PET, consistent with the histomorphological analysis [2]. Clinical indications: Colorectal tumor; Liver tumor FDA Approved Date: December 1970

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (609.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0619 mL 20.3095 mL 40.6190 mL
5 mM 0.8124 mL 4.0619 mL 8.1238 mL
10 mM 0.4062 mL 2.0310 mL 4.0619 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

246.19

Formula

C₉H₁₁FN₂O₅

CAS No.

50-91-9

SMILES

OC[[email protected]@H]1[[email protected]](C[[email protected]](N2C(NC(C(F)=C2)=O)=O)O1)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.93%

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Floxuridine
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HY-B0097
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Floxuridine

Cat. No.: HY-B0097