Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates

  • Bioorg Med Chem Lett. 2001 Nov 5;11(21):2803-5. doi: 10.1016/s0960-894x(01)00513-3.
E J McIntee  1 ,  C R Wagner
Affiliations
  • 1. Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
PMID: 11597404 DOI: 10.1016/s0960-894x(01)00513-3
Abstract

A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic Acid Phosphatase (hPAP).