Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines

  • Bioorg Med Chem Lett. 2010 Oct 1;20(19):5831-4. doi: 10.1016/j.bmcl.2010.07.126.
Sun Min Park  1 ,  Heeju Yang ,  Song-Kyu Park ,  Hwan Mook Kim ,  Byeang Hyean Kim
Affiliations
  • 1. Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
PMID: 20732810 DOI: 10.1016/j.bmcl.2010.07.126
Abstract

We have focused on the C5-modification of 2'-deoxyuridine with substituted heterocycles for bioactivity, such as Antiviral or Anticancer activity. Herein, we report a novel class of nucleoside analogues with perfluoroalkyltriazole moiety as an Anticancer drug candidate.