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  6. Irisquinone

Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks.

For research use only. We do not sell to patients.

Irisquinone Chemical Structure

Irisquinone Chemical Structure

CAS No. : 56495-82-0

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Irisquinone Related Antibodies

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Description

Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3].

In Vitro

Irisquinone (0-128 nM, 12-48 h) induces cell death of C6 rat glioma cells[2].
Irisquinone (4.2 nM, 48 h) increases the radiosensitivity of C6 rat glioma cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Irisquinone Related Antibodies

Cell Viability Assay[2]

Cell Line: C6 rat glioma cells
Concentration: 0, 4, 8, 16, 32, 64, 128 nM
Incubation Time: 12, 24, 48 h
Result: Time-dependently and dose-dependently inhibited cell viability.
In Vivo

Irisquinone (12.5 mg/kg, perfused daily) makes the rabbit VX2 lung transplant tumor wall thinner and the necrotic area larger in the irisquinone + radiotherapy group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbit bearing VX2 lung transplant tumor[1]
Dosage: 12.5 mg/kg
Administration: Perfused daily, starting from 3 days before irradiation to the end of irradiation.
Result: Displayed no significant difference of tumor growth between the radio therapy and Irisquinone + radiotherapy groups.
Showed thinner tumor wall and the larger necrotic area in the Irisquinone + radiotherapy group.
Molecular Weight

374.56

Formula

C24H38O3
CAS No.
SMILES

O=C1C(CCCCCCCCC/C=C\CCCCCC)=CC(C=C1OC)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Irisquinone56495-82-0OthersC6 rat gliomaradiation sensitizeranticancerGSHInhibitorinhibitorinhibit

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