56495-82-0
56495-82-0
Chemical Structure
Irisquinone
- CAS No.: 56495-82-0
- Formula:C24H38O3
- Molecular Weight:374.56
IUPAC Name: (Z)-2-(heptadec-10-en-1-yl)-6-methoxycyclohexa-2,5-diene-1,4-dione
InChIKey: YYCCUFKHCNSRIA-HJWRWDBZSA-N
SMILES: O=C1C(CCCCCCCCC/C=C\CCCCCC)=CC(C=C1OC)=O
Biological Activity: Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3].
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Irisquinone | Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks. | |||||||||||||||||||||
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References
- [1]. Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8. [Content Brief]
- [2]. Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14. [Content Brief]
- [3]. Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001).
