LEB-03-146
Based on 1 Customer Validation
LEB-03-146 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a PEG2 linker. LEB-03-146 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells.
For research use only. We do not sell to patients.
- Purity: 98.08%
- CAS No.: 2858812-91-4
- Formula: C46H57N11O8
- Molecular Weight:892.01
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2858812-91-4
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Appearance Solid
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Molecular Weight 892.01
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Formula C46H57N11O8
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Color Light yellow to yellow
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SMILES
C=CCN1C(C2=C(N1C3=NC(C(C)(O)C)=CC=C3)N=C(N=C2)NC4=CC=C(C=C4)N5CCN(CC5)CCOCCOCCNC(CCC6=CC=C(O6)N7CCN(CC7=O)C(C=C)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 50 mg/mL (56.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1211 mL | 5.6053 mL | 11.2106 mL | 28.0266 mL |
| 5 mM | 0.2242 mL | 1.1211 mL | 2.2421 mL | 5.6053 mL | |
| 10 mM | 0.1121 mL | 0.5605 mL | 1.1211 mL | 2.8027 mL | |
| 15 mM | 0.0747 mL | 0.3737 mL | 0.7474 mL | 1.8684 mL | |
| 20 mM | 0.0561 mL | 0.2803 mL | 0.5605 mL | 1.4013 mL | |
| 25 mM | 0.0448 mL | 0.2242 mL | 0.4484 mL | 1.1211 mL | |
| 30 mM | 0.0374 mL | 0.1868 mL | 0.3737 mL | 0.9342 mL | |
| 40 mM | 0.0280 mL | 0.1401 mL | 0.2803 mL | 0.7007 mL | |
| 50 mM | 0.0224 mL | 0.1121 mL | 0.2242 mL | 0.5605 mL |
LEB-03-146 Related Classifications
HY-144999 Related Classifications
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