2858812-91-4
Chemical Structure
LEB-03-146
- CAS No.: 2858812-91-4
- Formula:C46H57N11O8
- Molecular Weight:892.01
IUPAC Name: 3-(5-(4-acryloyl-2-oxopiperazin-1-yl)furan-2-yl)-N-(5-(4-(4-((2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)pentyl)propanamide
InChIKey: ZYUOWVKGQBMNGW-UHFFFAOYSA-N
SMILES: C=CCN1C(C2=C(N1C3=NC(C(C)(O)C)=CC=C3)N=C(N=C2)NC4=CC=C(C=C4)N5CCN(CC5)CCOCCOCCNC(CCC6=CC=C(O6)N7CCN(CC7=O)C(C=C)=O)=O)=O
Biological Activity: LEB-03-146 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a PEG2 linker. LEB-03-146 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LEB-03-146 | 98.08% | LEB-03-146 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a PEG2 linker. LEB-03-146 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells. | ||||||||||||||||||||
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Keywords
