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Cat. No.: HY-177928

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Adavosertib acid

(Synonyms: AZD1775 acid; MK-1775 acid)

Adavosertib (AZD1775; MK-1775) acid (Compound 9) is a derivative of AZD1775 (HY-10993) and can be used for the synthesis of PROTAC.

For research use only. We do not sell to patients.

CAS No.: 2714511-66-5
Formula: C₂₈H₃₂N₈O₄
Molecular Weight:544.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Adavosertib acid Chemical Structure

CAS No.: 2714511-66-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Adavosertib (AZD1775; MK-1775) acid (Compound 9) is a derivative of AZD1775 (HY-10993) and can be used for the synthesis of PROTAC^[1].

Chemical Information

CAS No. 2714511-66-5
Molecular Weight 544.60
Formula C₂₈H₃₂N₈O₄
SMILES

O=C(CN1CCN(CC1)C2=CC=C(NC3=NC=C4C(N(CC=C)N(C4=N3)C5=CC=CC(C(C)(C)O)=N5)=O)C=C2)O
Synonyms

AZD1775 acid; MK-1775 acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu S, et al. Design, synthesis, and biological evaluation of Wee1 kinase degraders. Eur J Med Chem. 2022 Dec 5;243:114786. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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