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Art. -Nr.: HY-190256

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WEE1 degrader-4

WEE1 degrader-4 (Example S1) is a WEE1 molecular glue degrader. WEE1 degrader-4 induces Cereblon-mediated ubiquitination and degradation of WEE1 kinase. WEE1 degrader-4 can be used in cancer research.

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CAS. Nr.: 3025468-20-3
Formel: C₂₇H₂₇N₅O₄
Molecular Weight:485.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

WEE1 degrader-4 Chemical Structure

CAS. Nr.: 3025468-20-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Cereblon

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

Alle Wee1 Isoform-spezifische Produkte anzeigen :

PKMYT1

In Vitro

Molecular glue degraders are a class of small-molecule compounds that induce or stabilize non-native protein-protein interactions (PPIs) between target proteins and E3 ubiquitin ligases; by promoting the polyubiquitination of target proteins, they ultimately achieve specific degradation of pathogenic proteins in a manner dependent on the ubiquitin-proteasome system (UPS).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3025468-20-3
Molecular Weight 485.53
Formel C₂₇H₂₇N₅O₄
SMILES

CC1=NC=C2C=C(CN3CC[C@H](OC4=CC5=C(C(N(C6CCC(NC6=O)=O)C5)=O)C=C4)C3)C=CC2=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. John Sapienza, et al. WEE1 kinase molecular glue degraders and uses thereof. WO2024006881A1. WIPO. 2024-01-04.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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WEE1 degrader-4

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen

Alle Wee1 Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

WEE1 degrader-4 Related Classifications

HY-190256 Related Classifications

Bioz

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