WEE1-IN-14
WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology.
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- No. CAS: 2803921-87-9
- Fòrmula: C25H25Cl2N7O
- Peso molecular:510.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 2803921-87-9
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Peso molecular 510.42
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Fòrmula C25H25Cl2N7O
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SMILES
O=C(N(C1=C(Cl)C=CC=C1Cl)CN2C)C3=C2C4=C(N=C3)NC(C5=CN(C6CCN(C)CC6)N=C5)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WEE1-IN-14 Related Classifications
HY-178150 Related Classifications
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