2803921-87-9
2803921-87-9
Chemical Structure
WEE1-IN-14
- CAS No.: 2803921-87-9
- Formula:C25H25Cl2N7O
- Molecular Weight:510.42
SMILES: O=C(N(C1=C(Cl)C=CC=C1Cl)CN2C)C3=C2C4=C(N=C3)NC(C5=CN(C6CCN(C)CC6)N=C5)=C4
Biological Activity: WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology[1].
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WEE1-IN-14 | WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology. | |||||||||||||||||||||
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References
Keywords
