Bosutinib isomer
Based on 1 Customer Validation
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.47%
- CAS 番号: 1391063-17-4
- 分子式: C26H29Cl2N5O3
- 分子量:530.45
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
1.6 μM
Compound: Bosutinib isomer
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Antiproliferative activity against HEK293T cells measured after 72 hrs by CellTiter-Blue assay
Antiproliferative activity against HEK293T cells measured after 72 hrs by CellTiter-Blue assay
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[PMID: 28792760] |
| MDA-MB-231 | IC50 |
1.8 μM
Compound: Bosutinib isomer
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Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CellTiter-Blue assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CellTiter-Blue assay
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[PMID: 28792760] |
| MM1.S | IC50 |
3.9 μM
Compound: Bosutinib isomer
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Antiproliferative activity against human MM1S cells measured after 72 hrs by CellTiter-Blue assay
Antiproliferative activity against human MM1S cells measured after 72 hrs by CellTiter-Blue assay
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[PMID: 28792760] |
体外実験
Bosutinib isomer (0-10 μM) shows the high growth inhibitory potential against HEK293T, MM1.S, and MDA-MB-231 cells, with IC50 values of 1.6 ± 0.19, 3.9 ± 0.50, and 1.8 ± 0.061 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1391063-17-4
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性状 Solid
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分子量 530.45
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分子式 C26H29Cl2N5O3
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Color Off-white to light yellow
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SMILES
N#CC1=C(NC2=CC(Cl)=C(OC)C(Cl)=C2)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (94.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8852 mL | 9.4260 mL | 18.8519 mL | 47.1298 mL |
| 5 mM | 0.3770 mL | 1.8852 mL | 3.7704 mL | 9.4260 mL | |
| 10 mM | 0.1885 mL | 0.9426 mL | 1.8852 mL | 4.7130 mL | |
| 15 mM | 0.1257 mL | 0.6284 mL | 1.2568 mL | 3.1420 mL | |
| 20 mM | 0.0943 mL | 0.4713 mL | 0.9426 mL | 2.3565 mL | |
| 25 mM | 0.0754 mL | 0.3770 mL | 0.7541 mL | 1.8852 mL | |
| 30 mM | 0.0628 mL | 0.3142 mL | 0.6284 mL | 1.5710 mL | |
| 40 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 1.1782 mL | |
| 50 mM | 0.0377 mL | 0.1885 mL | 0.3770 mL | 0.9426 mL | |
| 60 mM | 0.0314 mL | 0.1571 mL | 0.3142 mL | 0.7855 mL | |
| 80 mM | 0.0236 mL | 0.1178 mL | 0.2356 mL | 0.5891 mL |
Bosutinib isomer 関連分類
HY-103029 関連分類
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