Bosutinib isomer
Based on 1 Customer Validation
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 1391063-17-4
- Formula: C26H29Cl2N5O3
- Molecular Weight:530.45
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
1.6 μM
Compound: Bosutinib isomer
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Antiproliferative activity against HEK293T cells measured after 72 hrs by CellTiter-Blue assay
Antiproliferative activity against HEK293T cells measured after 72 hrs by CellTiter-Blue assay
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[PMID: 28792760] |
| MDA-MB-231 | IC50 |
1.8 μM
Compound: Bosutinib isomer
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Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CellTiter-Blue assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CellTiter-Blue assay
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[PMID: 28792760] |
| MM1.S | IC50 |
3.9 μM
Compound: Bosutinib isomer
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Antiproliferative activity against human MM1S cells measured after 72 hrs by CellTiter-Blue assay
Antiproliferative activity against human MM1S cells measured after 72 hrs by CellTiter-Blue assay
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[PMID: 28792760] |
Bosutinib isomer (0-10 μM) shows the high growth inhibitory potential against HEK293T, MM1.S, and MDA-MB-231 cells, with IC50 values of 1.6 ± 0.19, 3.9 ± 0.50, and 1.8 ± 0.061 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1391063-17-4
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Appearance Solid
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Molecular Weight 530.45
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Formula C26H29Cl2N5O3
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Color Off-white to light yellow
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SMILES
N#CC1=C(NC2=CC(Cl)=C(OC)C(Cl)=C2)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (94.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8852 mL | 9.4260 mL | 18.8519 mL | 47.1298 mL |
| 5 mM | 0.3770 mL | 1.8852 mL | 3.7704 mL | 9.4260 mL | |
| 10 mM | 0.1885 mL | 0.9426 mL | 1.8852 mL | 4.7130 mL | |
| 15 mM | 0.1257 mL | 0.6284 mL | 1.2568 mL | 3.1420 mL | |
| 20 mM | 0.0943 mL | 0.4713 mL | 0.9426 mL | 2.3565 mL | |
| 25 mM | 0.0754 mL | 0.3770 mL | 0.7541 mL | 1.8852 mL | |
| 30 mM | 0.0628 mL | 0.3142 mL | 0.6284 mL | 1.5710 mL | |
| 40 mM | 0.0471 mL | 0.2356 mL | 0.4713 mL | 1.1782 mL | |
| 50 mM | 0.0377 mL | 0.1885 mL | 0.3770 mL | 0.9426 mL | |
| 60 mM | 0.0314 mL | 0.1571 mL | 0.3142 mL | 0.7855 mL | |
| 80 mM | 0.0236 mL | 0.1178 mL | 0.2356 mL | 0.5891 mL |
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