FOXN2 - forkhead box N2 Gene

Also Known as HTLF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3344

About FOXN2

Cytogenetic location: 2p16.3 Genomic coordinates (GRCh38): 2:48,313,659-48,379,295 (from NCBI)

This gene has 2 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.2), fat (RPKM 8.5) and 24 other tissues.

Summary

This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

FOXN2 Products (13)

mRNA Protein Name
NM_001375442.1 NP_001362371.1 forkhead box protein N2 isoform a
NM_001375443.1 NP_001362372.1 forkhead box protein N2 isoform a
NM_001375444.1 NP_001362373.1 forkhead box protein N2 isoform a
NM_001375445.1 NP_001362374.1 forkhead box protein N2 isoform a
NM_001375446.1 NP_001362375.1 forkhead box protein N2 isoform a
NM_001375447.1 NP_001362376.1 forkhead box protein N2 isoform a
NM_001375448.1 NP_001362377.1 forkhead box protein N2 isoform a
NM_001375449.1 NP_001362378.1 forkhead box protein N2 isoform a
NM_001375450.1 NP_001362379.1 forkhead box protein N2 isoform a
NM_001375451.1 NP_001362380.1 forkhead box protein N2 isoform a
NM_001375452.1 NP_001362381.1 forkhead box protein N2 isoform a
NM_001375781.1 NP_001362710.1 forkhead box protein N2 isoform b
NM_002158.4 NP_002149.2 forkhead box protein N2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25609649 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN2 Protein Structure

Forkhead

Forkhead: Forkhead domain (112 - 200)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

forkhead box protein N2

  • human T-cell leukemia virus enhancer factor

FOXN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOXN2 P32314 FBXW11 Homo sapiens Q9UKB1
TAP
25609649
Intra
FOXN2 P32314 FBXW11 Homo sapiens Q9UKB1
Anti Tag CoIP
33961781
Intra
FOXN2 P32314 RFX1 Homo sapiens P22670
Pull Down
25609649
Intra
FOXN2 P32314 RFX1 Homo sapiens P22670
Anti Tag CoIP
33961781
Intra
FOXN2 P32314 RFX1 Homo sapiens P22670
Anti Tag CoIP
28514442
Intra
FOXN2 P32314 RFX1 Homo sapiens P22670
TAP
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05066 FOXN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FOXN2 VGNC VGNC:29096
Mus musculus FOXN2 MGD MGI:1347478
Canis familiaris FOXN2 VGNC VGNC:40961
Felis catus FOXN2 VGNC VGNC:80104
Macaca mulatta FOXN2 VGNC VGNC:72710
Rattus norvegicus FOXN2 RGD RGD:1562291
Others FOXN2 NCBI