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  2. Autophagy

DMXAA (Synonyms: ASA-404; Vadimezan)

Cat. No.: HY-10964 Purity: 99.19%
Data Sheet SDS Handling Instructions

DMXAA is a competitive inhibitor of the enzyme DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC 1.6.99.2) with respect to NADH, with Ki values of 20 μM.

For research use only. We do not sell to patients.
DMXAA Chemical Structure

DMXAA Chemical Structure

CAS No. : 117570-53-3

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10 mM * 1 mL in DMSO $88 In-stock
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10 mg $110 In-stock
50 mg $440 In-stock
100 mg $700 In-stock
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Description

DMXAA is a competitive inhibitor of the enzyme DT-diaphorase (NAD(P)H:Quinone oxidoreductase EC 1.6.99.2) with respect to NADH, with Ki values of 20 μM. [1] IC50 value: 20 μM (Ki) [1] Target: DT-diaphorase in vitro: DMXAA partially inhibits cytochrome b5 reductase activity. [1] DMXAA is a potent tumor blood vessel-disrupting agent and cytokine inducer used for the treatment of non-small cell lung cancer (NSCLC) and other cancers. DMXAA significantly induces G1 phase arrest in A549 cells. DMXAA induces apoptosis via a mitochondria-dependent pathway and promoted autophagy, as indicated by the increased level of cytosolic cytochrome c, activation of caspase 3, and enhances expression of beclin 1 and microtubule-associated protein 1A/1B-light chain 3 (LC3-II) in A549 cells. [2] in vivo: DMXAA has been shown to potentiate the antitumour activity of several bioreductive drugs in vivo. [1] In contrast, treatment with DMXAA results in a significant lower amount in the tumours when compared to the control mice.[3]

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References
Molecular Weight

282.29

Formula

C₁₇H₁₄O₄

CAS No.

117570-53-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
DMXAA
Cat. No.:
HY-10964
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