Il17f - interleukin 17F Gene

Also Known as IL-17F

Species: Mus musculus

Gene Type: protein coding
Gene ID: 257630

Summary

Enables cytokine receptor binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in defense response to bacterium and positive regulation of gene expression. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F). [provided by Alliance of Genome Resources, Apr 2022]

Il17f Products (1)

mRNA Protein Name
NM_145856.2 NP_665855.2 interleukin-17F precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine receptor binding IPI
IPI: Inferred from physical interaction
17911633 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18025225 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
18025225 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
18025225 MGI
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
19144317 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
19144317 MGI
involved in positive regulation of antimicrobial peptide production IDA
IDA: Inferred from direct assay
19144317 MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
16785495 MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response IGI
IGI: Inferred from genetic interaction
16785495 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
20554964 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16982811 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16982811 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17982105 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-17F

Recombinant Il17f Proteins

Cat. No. Product Name Accession Purity
HY-P72584 IL-17F Protein, Mouse (HEK293, His) Q7TNI7-1 (R29-A161) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74831 IL-17F Protein, Mouse Q7TNI7-1 (R21-A153) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77707 IL-17A/F Heterodimer Protein, Mouse (HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7 (R29-A161) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77708 IL-17A/F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7-1 (R29-A161) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78160 IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi) Q7TNI7-1 (R29-A161) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78321 IL-17F Protein, Mouse (HEK293, His-Avi) Q7TNI7-1 (R29-A161) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700195AF Animal-Free IL-17F Protein, Mouse (His) Q7TNI7-1 (R29-A161) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99280 Bimekizumab Antagonist 99.52% Unkown

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99397 Sonelokimab Inhibitor 99.81% Phase 3

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1924 IRBP(651-670) human, mouse Activator 99.64% Unkown
HY-124686 ER-464195-01 Inhibitor 99.72% Unkown
HY-153276 Androgen receptor-IN-5 Inhibitor / Unkown
HY-168971 Paeoniflorin-6′-O-benzene sulfonate / Unkown
HY-183370 JAK2/STAT3-IN-2 Inhibitor / Unkown
HY-P1924A IRBP(651-670) human, mouse TFA Activator / Unkown
HY-RS06701 IL17F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17703 Il17f Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24167 Il17f Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99424 Afasevikumab Inhibitor 95% Unkown
HY-P990221 Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Inhibitor ≥95.0% Unkown
HY-P992236 Anti-IL-17F Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il17f NCBI NCBI:112744