IL17F - interleukin 17F Gene

Also Known as ML1; ML-1; IL17A; CANDF6; IL-17F

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112744

About IL17F

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,236,681-52,245,689 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues, 5 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several Other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

IL17F Products (1)

mRNA	Protein	Name
NM_052872.4	NP_443104.1	interleukin-17F precursor

IL17F Protein Structure

IL17

0
100
163 a.a.

Protein Preferred Names	Protein Names
interleukin-17F	cytokine ML-1

Recombinant IL17F Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7209	IL-17F Protein, Human	Q96PD4 (R31-Q163)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70540	IL-17F Protein, Human (HEK293, His)	Q96PD4/AAH70124.1 (R31-Q163)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72586	IL-17F Protein, Human (HEK293)	Q96PD4/AAH70124.1 (R31-Q163)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72589	IL-17A/F Heterodimer Protein, Human (HEK293, His)	Q16552 (G24-A155)&AAH70124.1 (R31-Q163)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77713	IL-17A/F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)	Q16552 (G24-A155)&Q96PD4 (R31-Q163)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78159	IL-17F Protein, Human (Biotinylated, HEK293, His-Avi)	Q96PD4 (R31-Q163)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78669	IL-17F Protein, Human (H161R, HEK293, His)	Q96PD4 (R31-Q163, H161R)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700107AF	Animal-Free IL-17F Protein, Human (His)	Q96PD4 (R31-Q163)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Candidiasis, Familial, 6	CANDF6 Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant Candidiasis, Familial, 6, Autosomal Dominant Autosomal Dominant Candidiasis Familial Chronic Mucocutaneous Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome Candf7 Candidiasis Familial, 7 Familial Chronic Mucocutaneous, Autosomal Dominant Immunodeficiency 31c Imd31c Candidiasis Familial Chronic Mucocutaneous Autosomal Dominant Chronic Mucocutaneous Candidiasis 6 Candidiasis, Familial, Type 6 Candidiasis, Familial, 7
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Acute Generalized Exanthematous Pustulosis	Agep Pustular Drug Eruption Toxic Pustuloderma
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Mouth Disease	Mouth Diseases Mouth Disorders
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly
Cutaneous Candidiasis	Candidiasis, Cutaneous
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Complement Component 6 Deficiency	C6 Deficiency C6D C6 Deficiency Subtotal Complement Component 6 Deficiency Subtotal C6 Deficiency, Subtotal
Hyper Ige Recurrent Infection Syndrome 1	Job Syndrome Hyper-Ige Recurrent Infection Syndrome 1 Hyperimmunoglobulin E Syndrome Job'S Syndrome Recurring Cold Staphylococcal Abscesses Ige Syndromes Buckley Syndrome Hie - [Hyperimmunoglobulin E] Syndrome Job-Buckley Syndrome Quie-Hill Syndrome
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Autoimmune Disease Of Skin And Connective Tissue
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Fungal Infectious Disease	Mycoses Mycosis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Dermatophytosis	Tinea Dermatophytosis, Unspecified Ringworm Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton Cutaneous Mycosis Dermal Mycosis Superficial Mycosis, Unspecified Fungus Infection Of Skin Skin Mycosis Dermatitis Fungoid Fungal Dermatitis Fungal Dermatosis Mycotic Infection Of Skin
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Pustulosis Of Palm And Sole	Psoriasis Acropustulosis Palmoplantar Pustulosis Pustular Psoriasis Of The Palms And/Or Soles Pustulosis Of Palms And Soles Acrodermatitis Continua Of Hallopeau Generalized Pustular Psoriasis
Psoriasis
Autoimmune Uveitis
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Autoimmune Disease Of Musculoskeletal System
Integumentary System Disease
Ankylosing Spondylitis 1	Ankylosing Spondylitis, Susceptibility To, 1
Autoimmune Disease Of Central Nervous System
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL17F	RGD	RGD:1311398
Macaca mulatta	IL17F	VGNC	VGNC:81082
Mus musculus	IL17F	MGD	MGI:2676631
Felis catus	IL17F	VGNC	VGNC:102442
Canis familiaris	IL17F	VGNC	VGNC:41945
Bos taurus	IL17F	VGNC	VGNC:30121
Others	IL17F	NCBI