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Uteroglobin/SCGB1A1 Protein, Human

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Based on 1 Customer Validation

Uteroglobin/SCGB1A1 Protein displays diverse binding, including phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB), and weakly binds progesterone. It acts as a robust inhibitor of phospholipase A2, structurally forming a disulfide-linked antiparallel homodimer. Controversy surrounds its interaction with LMBR1L, necessitating further investigation. Uteroglobin/SCGB1A1 Protein, Human is the recombinant human-derived Uteroglobin/SCGB1A1 protein, expressed by E. coli , with tag free.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: E. coli
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Experimental Validation Results for Uteroglobin/SCGB1A1 Protein, Human
  • Experimental Validation Results for Uteroglobin/SCGB1A1 Protein, Human
  • Uteroglobin/SCGB1A1 Protein, Human Product Image
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[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

Uteroglobin/SCGB1A1 Protein displays diverse binding, including phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB), and weakly binds progesterone. It acts as a robust inhibitor of phospholipase A2, structurally forming a disulfide-linked antiparallel homodimer. Controversy surrounds its interaction with LMBR1L, necessitating further investigation. Uteroglobin/SCGB1A1 Protein, Human is the recombinant human-derived Uteroglobin/SCGB1A1 protein, expressed by E. coli , with tag free.

Background

The Uteroglobin/SCGB1A1 protein exhibits versatile binding capabilities, including the ability to bind phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB), and weakly binds progesterone. Additionally, it functions as a potent inhibitor of phospholipase A2. Structurally, this protein forms an antiparallel homodimer that is disulfide-linked. While there is some controversy surrounding its interaction with LMBR1L, further investigation is required to clarify this aspect.

Verified Bioactivity

Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells. The ED50 for this effect is typically < 1 μg/mL.

MCE Validation Data

  • Purity - SDS-PAGE

    Purity - SDS-PAGE

    ≥ 95%, as determined by reducing SDS-PAGE.

  • Bioactivity - Cell-Based Assay

    Bioactivity - Cell-Based Assay

    Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells. The ED50 for this effect is typically 0.2278 μg/mL, corresponding to a specific activity is 4.390×103 units/mg.

Technical Parameters

  • Species Human
  • Source E. coli
  • Tag Tag Free
  • Accession

    P11684 (E22-N91)

  • Gene ID
    7356  [NCBI]
  • Molecular Construction
    • N-term
    • SCGB1A1 (E22-N91)
      Accession # P11684
    • C-term
  • Protein Length

    Full Length of Mature Protein

  • Synonyms

    SCGB1A1; Urinary Protein 1; Prev. UGB; CCPBP; Uteroglobin; UP-1; CC10; UP1; CCSP; Secretoglobin, Family 1A, Member 1 (Uteroglobin); CC16; Uteroglobin (Clara Cell Specific 10-KD Protein); Club Cell Phospholipid-Binding Protein; Uteroglobin (Club-Cell Speci

  • AA Sequence

    EICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN

  • Molecular Weight

    Approximately 8 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Desired Reconstitution Concentration Desired Reconstitution Concentration
Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • 1/16

    MedChemExpress Validation
     Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells. The ED50 for this effect is typically 0.2278 μg/mL, corresponding to a specific activity is 4.390×103 units/mg.

  • Uteroglobin/SCGB1A1 Protein, Human Product Image
    1/16
  • Experimental Validation Results for Uteroglobin/SCGB1A1 Protein, Human
  • Experimental Validation Results for Uteroglobin/SCGB1A1 Protein, Human
  • Uteroglobin/SCGB1A1 Protein, Human Product Image