SCGB1A1 - secretoglobin family 1A member 1 Gene

Also Known as UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7356

About SCGB1A1

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,419,033-62,423,195 (from NCBI)

This gene has 2 transcripts (splice variants), 63 orthologues and 2 paralogues. Restricted expression toward lung (RPKM 1367.3).

Summary

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of Phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

SCGB1A1 Products (1)

mRNA	Protein	Name
NM_003357.5	NP_003348.1	uteroglobin precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16423471	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCGB1A1 Protein Structure

Uteroglobin

0
91 a.a.

Protein Preferred Names	Protein Names
uteroglobin	Uteroglobin (club-cell specific 10-kD protein)

SCGB1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCGB1A1	P11684	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	SCGB1A1	P11684	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SCGB1A1	P11684	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SCGB1A1	P11684	GATM	Homo sapiens	P50440	Validated Y2H	32814053
Intra	SCGB1A1	P11684	GATM	Homo sapiens	P50440	Y2H Array	32814053
Intra	SCGB1A1	P11684	GATM	Homo sapiens	P50440	Y2H Pooling	32814053
Intra	SCGB1A1	P11684	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	33961781
Intra	SCGB1A1	P11684	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	28514442
Intra	SCGB1A1	P11684	HSF1	Homo sapiens	Q00613	Y2H Pooling	32814053
Intra	SCGB1A1	P11684	HSF1	Homo sapiens	Q00613	Validated Y2H	32814053
Intra	SCGB1A1	P11684	HSF1	Homo sapiens	Q00613	Y2H Array	32814053
Intra	SCGB1A1	P11684	TMEM43	Homo sapiens	Q9BTV4	Y2H Array	32296183
Intra	SCGB1A1	P11684	TMEM43	Homo sapiens	Q9BTV4	Y2H Prey Pooling	32296183
Intra	SCGB1A1	P11684	TMEM43	Homo sapiens	Q9BTV4	Validated Y2H	32296183
Intra	SCGB1A1	P11684	TRIM32	Homo sapiens	Q13049	Validated Y2H	32296183
Intra	SCGB1A1	P11684	TRIM32	Homo sapiens	Q13049	Y2H Array	31515488
Intra	SCGB1A1	P11684	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
Intra	SCGB1A1	P11684	TRIM32	Homo sapiens	Q13049	Y2H Array	25416956
Intra	SCGB1A1	P11684	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCGB1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71107	Uteroglobin/SCGB1A1 Protein, Human (HEK293, His)	P11684 (E22-N91)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71933	Uteroglobin/SCGB1A1 Protein, Human	P11684 (E22-N91)	≥ 95%, as determined by reducing SDS-PAGE.

SCGB1A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81787	Uteroglobin Antibody (YA1532)	WB, FC	Human, Mouse, Rat
HY-P84065	Uteroglobin Antibody (YA3762)	FC, ELISA	Human
HY-P84065A	Uteroglobin Antibody (YA3762)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Silicosis	Silicotuberculosis Acute Silicosis Chronic Silicosis Pneumoconiosis Due To Silicates Silica Pneumoconiosis Silicotic Fibrosis Of Lung Accelerated Silicosis Experimental Silicosis
Bronchopulmonary Dysplasia	Bpd
Bronchiolitis Obliterans	Bronchiolitis Fibrosa Obliterans Obliterative Bronchiolitis Bronchiolitis Exudativa Bronchiolitis, Exudative
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Meconium Aspiration Syndrome	Neonatal Aspiration Of Meconium Meconium Aspiration Mas Meconium Aspiration Syndrome Of Newborn Meconium Inhalation Mas - [Meconium Aspiration Syndrome] Meconium Aspiration Nos Meconium Aspiration Syndrome Nos Meconium Pneumonitis Meconium Stained Liqueur Aspiration
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Maple Bark Strippers' Lung	Alveolitis Due To Cryptostroma Corticale Maple-Bark Strippers' Lung Maple Bark Disease Maple Bark Stripper'S Disease Maple Bark Stripper'S Lung Maple Bark-Strippers' Lung Cryptostromosis Maple-Bark Disease Maple-Bark Strippers' Disease
Rhinitis	Runny Nose
Alveoli Adenoma	Alveolar Adenoma Adenoma Of Alveoli Adenoma Of The Alveoli
Bronchial Benign Neoplasm	Bronchus Neoplasm Neoplasm Of Bronchus Bronchial Neoplasms Bronchial Neoplasm
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Toxic Pneumonitis	Acute Chemical Fume Pulmonary Edema Acute Chemical Pulmonary Edema Acute Pulmonary Edema Due To Fumes And/Or Vapors
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Glomerulonephritis	Bright'S Disease
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Respiratory System Benign Neoplasm
Pulmonary Edema
Exercise-Induced Bronchoconstriction	Exercise-Induced Asthma Asthma Exercise-Induced
Lung Adenoma	Adenoma Of Lung Pulmonary Adenoma
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Subleukemic Leukemia	Aleukemic Leukemia Cutis Leukemia Subleukemic
Cork-Handlers' Disease	Suberosis Cork-Handlers' Disease Or Lung Cork-Handlers' Lung Corkhandler Disease Corkworker Lung Corkhandler Hypersensitivity Pneumonitis Cork-Handler Disease Cork-Handler Lung
Malt Worker'S Lung	Alveolitis Due To Aspergillus Clavatus Malt Worker Lung Malt Workers' Lung Malt-Workers' Lung Malt Fever Malt House Workers' Cough Malt-Workers' Alveolitis Malt-Workers' Lung Disease Alveolitis Due To Aspergillus Fumigatus Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Anthracosilicosis
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Granulomatous Endometritis
Neonatal Respiratory Failure	Respiratory Failure Of Newborn Inadequate Pulmonary Ventilation Of Newborn Newborn Lung Insufficiency Newborn Pulmonary Function Inadequate Newborn Pulmonary Insufficiency Newborn Respiration Failure Newborn Respiratory Insufficiency Respiratory Insufficiency Syndrome Of Newborn
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Intrinsic Asthma	Non-Atopic Asthma
Papillary Adenoma	Glandular Papilloma Adenoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12504	SCGB1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18577	Scgb1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25061	Scgb1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCGB1A1	RGD	RGD:3934
Felis catus	SCGB1A1	VGNC	VGNC:64911
Bos taurus	SCGB1A1	VGNC	VGNC:34335
Macaca mulatta	SCGB1A1	VGNC	VGNC:77004
Canis familiaris	SCGB1A1	VGNC	VGNC:45908
Mus musculus	SCGB1A1	MGD	MGI:98919
Others	SCGB1A1	NCBI