IVNS1ABP Protein, Human (sf9, His, StrepⅡ)

The IVNS1ABP protein is intricately involved in diverse cellular functions, encompassing pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It plays a crucial role in the dynamic organization of the actin skeleton by stabilizing actin filaments through its association with F-actin via Kelch repeats, thereby protecting cells from cell death induced by actin destabilization. Moreover, IVNS1ABP serves as a modifier of the AHR pathway, enhancing the concentration of AHR available for transcriptional activation. Additionally, it acts as a negative regulator of the BCR(KLHL20) E3 ubiquitin ligase complex, preventing ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Furthermore, IVNS1ABP inhibits pre-mRNA splicing in vitro and is implicated in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, facilitating the generation of the viral M2 protein. These multifaceted functions highlight the diverse and crucial roles played by IVNS1ABP in cellular processes and responses.