SIRP beta 1 Protein, Human (isoform 3, HEK293, His-Avi)
SIRP Beta 1 Protein, an immunoglobulin-like cell surface receptor, crucially negatively regulates receptor tyrosine kinase-coupled signaling processes. It modulates cellular responses to stimuli like cell adhesion, growth factors, or insulin, contributing to maintaining cellular homeostasis and finely tuning signaling pathways associated with receptor tyrosine kinases. SIRP beta 1 Protein, Human (isoform 3, HEK293, His-Avi) is the recombinant human-derived SIRP Beta 1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
SIRP Beta 1 Protein, an immunoglobulin-like cell surface receptor, crucially negatively regulates receptor tyrosine kinase-coupled signaling processes. It modulates cellular responses to stimuli like cell adhesion, growth factors, or insulin, contributing to maintaining cellular homeostasis and finely tuning signaling pathways associated with receptor tyrosine kinases. SIRP beta 1 Protein, Human (isoform 3, HEK293, His-Avi) is the recombinant human-derived SIRP Beta 1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
Background
SIRP Beta 1 Protein, an immunoglobulin-like cell surface receptor, plays a crucial role in negatively regulating receptor tyrosine kinase-coupled signaling processes. This receptor modulates cellular responses induced by various stimuli, including cell adhesion, growth factors, or insulin. Through its regulatory functions, SIRP Beta 1 contributes to maintaining cellular homeostasis and finely tuning the activation of signaling pathways associated with receptor tyrosine kinases.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-6*His
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Accession
Q5TFQ8 (E30-L371)
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Molecular Construction
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N-term
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SIRP Beta 1 (E30-L371)
Accession # Q5TFQ8 -
6*His-Avi
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C-term
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Protein Length
Extracellular Domain
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Synonyms
SIRPB1; Signal-Regulatory Protein Beta-1 Isoform 3; Signal Regulatory Protein Beta 1; Signal-Regulatory Protein Beta 1; SIRP-BETA-1; Alternative Protein SIRPB1; CD172b; SIRP-Beta-1 Isoform 3; CD172 Antigen-Like Family Member B; CD172b Antigen; Signal-Regu
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AA Sequence
EEELQVIQPDKSISVAAGESATLHCTVTSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPADAGTYYCVKFRKGSPDHVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTLTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAPGPALASAAPL
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Predicted Molecular Mass
39.9 kDa
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Molecular Weight
Approximately 60-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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