2. Gene
  3. SIRPB1 - signal regulatory protein beta 1 Gene

SIRPB1 - signal regulatory protein beta 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD172b; SIRP-BETA-1

Gene ID: 10326 | Gene type: protein coding

About SIRPB1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,561,385-1,620,009 (from NCBI)

This gene has 15 transcripts (splice variants), 289 orthologues and 4 paralogues. Broad expression in appendix (RPKM 6.6), bone marrow (RPKM 6.0) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase Syk. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

SIRPB1 Products(5)

mRNA Protein Name
NM_001083910.4 NP_001077379.1 signal-regulatory protein beta-1 isoform 2 precursor
NM_001135844.4 NP_001129316.1 signal-regulatory protein beta-1 isoform 3 precursor
NM_001329157.2 NP_001316086.1 signal-regulatory protein beta-1 isoform 3 precursor
NM_001330639.2 NP_001317568.1 signal-regulatory protein beta-1 isoform 4 precursor
NM_006065.5 NP_006056.2 signal-regulatory protein beta-1 isoform 1 precursor

SIRPB1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (34 - 143)

C1-set

C1-set: Immunoglobulin C1-set domain (162 - 235)

C1-set

C1-set: Immunoglobulin C1-set domain (263 - 338)

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  • 398 a.a.
Protein Preferred Names Protein Names

signal-regulatory protein beta-1

CD172 antigen-like family member B

Recombinant SIRPB1 Proteins

Cat. No. Product Name Accession Purity
HY-P70719 SIRP beta 1 Protein, Human (HEK293, His) O00241 (E30-E362) ≥95%
HY-P77838 SIRP Beta 1 Protein, Human (isoform 3, HEK293, His-Avi) Q5TFQ8 (E30-L371) ≥95%
HY-P77839 SIRP Beta 1 Protein, Human (Biotinylated, isoform 3, HEK293, His-Avi) Q5TFQ8 (E30-L371) ≥95%
HY-P78520 SIRP Beta 1 Protein, Human (HEK293, His-Avi) O00241 (E30-A369) ≥95%
HY-P700645 SIRP beta 1 Protein, Human (HEK293, His-Myc) O00241 (E30-L371) ≥95%
HY-P700827 SIRP Beta 1 Protein, Human (Biotinylated, HEK293, C-His-Avi) O00241-1 (E30-A369) ≥95%

Related Diseases

Diseases Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12933 SIRPB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIRPB1 NCBI