SIRPB1 - signal regulatory protein beta 1 Gene
Also Known as CD172b; SIRP-BETA-1
Species: Homo sapiens
About SIRPB1
This gene has 15 transcripts (splice variants), 289 orthologues and 4 paralogues. Broad expression in appendix (RPKM 6.6), bone marrow (RPKM 6.0) and 22 other tissues.
Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase Syk. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
SIRPB1 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001083910.4 | NP_001077379.1 | signal-regulatory protein beta-1 isoform 2 precursor |
| NM_001135844.4 | NP_001129316.1 | signal-regulatory protein beta-1 isoform 3 precursor |
| NM_001329157.2 | NP_001316086.1 | signal-regulatory protein beta-1 isoform 3 precursor |
| NM_001330639.2 | NP_001317568.1 | signal-regulatory protein beta-1 isoform 4 precursor |
| NM_006065.5 | NP_006056.2 | signal-regulatory protein beta-1 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10940905 | GOA |
SIRPB1 Protein Structure
V-set: Immunoglobulin V-set domain (34 - 143)
C1-set: Immunoglobulin C1-set domain (162 - 235)
C1-set: Immunoglobulin C1-set domain (263 - 338)
- 0
- 100
- 200
- 300
- 398 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
signal-regulatory protein beta-1 |
|
SIRPB1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SIRPB1 | O00241 | TYROBP | Homo sapiens | O43914 | 10940905 |
Recombinant SIRPB1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70719 | SIRP beta 1 Protein, Human (HEK293, His) | O00241-1 (E30-E362) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77838 | SIRP beta 1 Protein, Human (isoform 3, HEK293, His-Avi) | Q5TFQ8 (E30-L371) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77839 | SIRP beta 1 Protein, Human (Biotinylated, isoform 3, HEK293, His-Avi) | Q5TFQ8 (E30-L371) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78520 | SIRP beta 1 Protein, Human (HEK293, His-Avi) | O00241-1 (E30-A369) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700645 | SIRP beta 1 Protein, Human (HEK293, His-Myc) | O00241-1 (E30-L371) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P700827 | SIRP beta 1 Protein, Human (Biotinylated, HEK293, C-His-Avi) | O00241-1 (E30-A369) | ≥ 95%, as determined by reducing SDS-PAGE. |
SIRPB1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83788 | CD172b Antibody (YA3485) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P83788A | CD172b Antibody (YA3485)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS12933 | SIRPB1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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