TYROBP - transmembrane immune signaling adaptor TYROBP Gene

Also Known as DAP12; KARAP; PLOSL; PLOSL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7305

About TYROBP

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,904,403-35,908,295 (from NCBI)

This gene has 9 transcripts (splice variants), 101 orthologues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 147.9), spleen (RPKM 124.2) and 20 other tissues.

Summary

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (Syk) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

TYROBP Products (4)

mRNA	Protein	Name
NM_001173514.2	NP_001166985.1	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
NM_001173515.2	NP_001166986.1	TYRO protein tyrosine kinase-binding protein isoform 4 precursor
NM_003332.4	NP_003323.1	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
NM_198125.3	NP_937758.1	TYRO protein tyrosine kinase-binding protein isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20890284	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	10799849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9655483	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9655483	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	23459077	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11602640	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance	IDA IDA: Inferred from direct assay	27477018	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	23459077	GOA
involved in myeloid leukocyte activation	IDA IDA: Inferred from direct assay	10604985	GOA
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	21727189	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	26358190	GOA
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	GOA
involved in positive regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	18957693	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	23715743	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	25957402	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23715743	GOA
involved in stimulatory C-type lectin receptor signaling pathway	IDA IDA: Inferred from direct assay	9655483	GOA
involved in stimulatory killer cell immunoglobulin-like receptor signaling pathway	IDA IDA: Inferred from direct assay	9655483	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cell surface	IDA IDA: Inferred from direct assay	10799849	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15294961	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	23459077	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9655483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TYRO protein tyrosine kinase-binding protein	DNAX adaptor protein 12

TYROBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TYROBP	O43914	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	TYROBP	O43914	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	TYROBP	O43914	TYROBP	Homo sapiens	O43914	NMR	20890284
Intra	TYROBP	O43914	TYROBP	Homo sapiens	O43914	Comig Non-Denat Gel	20890284
Intra	TYROBP	O43914	SIRPB1	Homo sapiens	O00241	Anti Bait CoIP	10940905
Intra	TYROBP	O43914	SIRPB1	Homo sapiens	O00241	Anti Tag CoIP	10940905
Intra	TYROBP	O43914	dap12-tm_nkg2c-tm_fusion_protein	Homo sapiens	EBI-16420154	NMR	20890284

Cross: Cross-species interaction Intra: Intraspecies interaction

TYROBP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81906	DAP12 Antibody (YA1651)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Solitary Bone Cyst	Unicameral Bone Cyst Bone Cysts Cyst Of Bone Local Cyst Of Bone Simple Bone Cyst Solitary Bone Cyst, Unspecified Site Traumatic Bone Cyst
Amyotrophic Lateral Sclerosis 3	ALS3 Amyotrophic Lateral Sclerosis Type 3
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1	Hereditary Diffuse Leukoencephalopathy With Spheroids Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Alsp Gpsc Subcortical Gliosis Of Neumann Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1 Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids Hdls HDLS1 Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia Gliosis, Familial Progressive Subcortical Leukoencephalopathy, Diffuse Hereditary, With Spheroids Pold Pigmentary Orthochromatic Leukodystrophy Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Familial Progressive Subcortical Gliosis Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant Dementia, Familial, Neumann Type Adult-Onset Leukodystrophy With Neuroaxonal Spheroids Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids Neuroaxonal Leukodystrophy Fpsg Familial Dementia, Neumann Type Familial Dementia Neumann Type Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Speech Disorder	Speech Disorders
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15309	TYROBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21215	Tyrobp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27731	Tyrobp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TYROBP	VGNC	VGNC:48028
Felis catus	TYROBP	VGNC	VGNC:66740
Mus musculus	TYROBP	MGD	MGI:1277211
Rattus norvegicus	TYROBP	RGD	RGD:1303081
Bos taurus	TYROBP	VGNC	VGNC:36552
Others	TYROBP	NCBI